The transcription factor TCFL5 responds to A MYB to elaborate the male meiotic program in mice
Authors
Cecchini, KatharineBiasini, Adriano
Yu, Tianxiong
Säflund, Martin
Mou, Haiwei
Arif, Amena
Eghbali, Atiyeh
Colpan, Cansu
Gainetdinov, Ildar
de Rooij, Dirk G
Weng, Zhiping
Zamore, Phillip
Ozata, Deniz M
Document Type
Accepted ManuscriptPublication Date
2022-11-01
Metadata
Show full item recordAbstract
In male mice, the transcription factors STRA8 and MEISON initiate meiosis I. We report that STRA8/MEISON activates the transcription factors A MYB and TCFL5, which together reprogram gene expression after spermatogonia enter into meiosis. TCFL5 promotes transcription of genes required for meiosis, mRNA turnover, miR-34/449 production, meiotic exit, and spermiogenesis. This transcriptional architecture is conserved in rhesus macaque, suggesting TCFL5 plays a central role in meiosis and spermiogenesis in placental mammals. Tcfl5em1/em1 mutants are sterile, and spermatogenesis arrests at the mid- or late-pachytene stage of meiosis. Moreover, Tcfl5+/em1 mutants produce fewer motile sperm.Source
Cecchini K, Biasini A, Yu T, Säflund M, Mou H, Arif A, Eghbali A, Colpan C, Gainetdinov I, de Rooij DG, Weng Z, Zamore P, Ozata DM. The transcription factor TCFL5 responds to A MYB to elaborate the male meiotic program in mice. Reproduction. 2022 Nov 1:REP-22-0355. doi: 10.1530/REP-22-0355. Epub ahead of print. PMID: 36395073.DOI
10.1530/REP-22-0355Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51455PubMed ID
36395073Rights
Copyright: © 2022 Society for Reproduction and Fertility 2022. This is a PDF file of the accepted manuscript that has been posted as allowed by the publisher's open access policy at https://eje.bioscientifica.com/page/open-access/open-access-policy.ae974a485f413a2113503eed53cd6c53
10.1530/REP-22-0355