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    The transcription factor TCFL5 responds to A MYB to elaborate the male meiotic program in mice

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    Authors
    Cecchini, Katharine
    Biasini, Adriano
    Yu, Tianxiong
    Säflund, Martin
    Mou, Haiwei
    Arif, Amena
    Eghbali, Atiyeh
    Colpan, Cansu
    Gainetdinov, Ildar
    de Rooij, Dirk G
    Weng, Zhiping
    Zamore, Phillip
    Ozata, Deniz M
    Show allShow less
    UMass Chan Affiliations
    Program in Bioinformatics and Integrative Biology
    RNA Therapeutics Institute
    Document Type
    Accepted Manuscript
    Publication Date
    2022-11-01
    Keywords
    TCFL5
    spermatogenesis
    meiosis
    A-MYB
    transcription factors network
    miR-34/449
    
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    Link to Full Text
    https://doi.org/10.1530/rep-22-0355
    Abstract
    In male mice, the transcription factors STRA8 and MEISON initiate meiosis I. We report that STRA8/MEISON activates the transcription factors A MYB and TCFL5, which together reprogram gene expression after spermatogonia enter into meiosis. TCFL5 promotes transcription of genes required for meiosis, mRNA turnover, miR-34/449 production, meiotic exit, and spermiogenesis. This transcriptional architecture is conserved in rhesus macaque, suggesting TCFL5 plays a central role in meiosis and spermiogenesis in placental mammals. Tcfl5em1/em1 mutants are sterile, and spermatogenesis arrests at the mid- or late-pachytene stage of meiosis. Moreover, Tcfl5+/em1 mutants produce fewer motile sperm.
    Source
    Cecchini K, Biasini A, Yu T, Säflund M, Mou H, Arif A, Eghbali A, Colpan C, Gainetdinov I, de Rooij DG, Weng Z, Zamore P, Ozata DM. The transcription factor TCFL5 responds to A MYB to elaborate the male meiotic program in mice. Reproduction. 2022 Nov 1:REP-22-0355. doi: 10.1530/REP-22-0355. Epub ahead of print. PMID: 36395073.
    DOI
    10.1530/REP-22-0355
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/51455
    PubMed ID
    36395073
    Rights
    Copyright: © 2022 Society for Reproduction and Fertility 2022. This is a PDF file of the accepted manuscript that has been posted as allowed by the publisher's open access policy at https://eje.bioscientifica.com/page/open-access/open-access-policy.
    ae974a485f413a2113503eed53cd6c53
    10.1530/REP-22-0355
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