The transcription factor TCFL5 responds to A MYB to elaborate the male meiotic program in mice
de Rooij, Dirk G
Ozata, Deniz M
UMass Chan AffiliationsProgram in Bioinformatics and Integrative Biology
RNA Therapeutics Institute
Document TypeAccepted Manuscript
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AbstractIn male mice, the transcription factors STRA8 and MEISON initiate meiosis I. We report that STRA8/MEISON activates the transcription factors A MYB and TCFL5, which together reprogram gene expression after spermatogonia enter into meiosis. TCFL5 promotes transcription of genes required for meiosis, mRNA turnover, miR-34/449 production, meiotic exit, and spermiogenesis. This transcriptional architecture is conserved in rhesus macaque, suggesting TCFL5 plays a central role in meiosis and spermiogenesis in placental mammals. Tcfl5em1/em1 mutants are sterile, and spermatogenesis arrests at the mid- or late-pachytene stage of meiosis. Moreover, Tcfl5+/em1 mutants produce fewer motile sperm.
SourceCecchini K, Biasini A, Yu T, Säflund M, Mou H, Arif A, Eghbali A, Colpan C, Gainetdinov I, de Rooij DG, Weng Z, Zamore P, Ozata DM. The transcription factor TCFL5 responds to A MYB to elaborate the male meiotic program in mice. Reproduction. 2022 Nov 1:REP-22-0355. doi: 10.1530/REP-22-0355. Epub ahead of print. PMID: 36395073.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/51455
RightsCopyright: © 2022 Society for Reproduction and Fertility 2022. This is a PDF file of the accepted manuscript that has been posted as allowed by the publisher's open access policy at https://eje.bioscientifica.com/page/open-access/open-access-policy.