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dc.contributor.authorPunches, Brittany E
dc.contributor.authorStolz, Uwe
dc.contributor.authorFreiermuth, Caroline E
dc.contributor.authorAncona, Rachel M
dc.contributor.authorMcLean, Samuel A
dc.contributor.authorHouse, Stacey L
dc.contributor.authorBeaudoin, Francesca L
dc.contributor.authorAn, Xinming
dc.contributor.authorStevens, Jennifer S
dc.contributor.authorZeng, Donglin
dc.contributor.authorNeylan, Thomas C
dc.contributor.authorClifford, Gari D
dc.contributor.authorJovanovic, Tanja
dc.contributor.authorLinnstaedt, Sarah D
dc.contributor.authorGermine, Laura T
dc.contributor.authorBollen, Kenneth A
dc.contributor.authorRauch, Scott L
dc.contributor.authorHaran, John P
dc.contributor.authorStorrow, Alan B
dc.contributor.authorLewandowski, Christopher
dc.contributor.authorMusey, Paul I
dc.contributor.authorHendry, Phyllis L
dc.contributor.authorSheikh, Sophia
dc.contributor.authorJones, Christopher W
dc.contributor.authorKurz, Michael C
dc.contributor.authorGentile, Nina T
dc.contributor.authorMcGrath, Meghan E
dc.contributor.authorHudak, Lauren A
dc.contributor.authorPascual, Jose L
dc.contributor.authorSeamon, Mark J
dc.contributor.authorHarris, Erica
dc.contributor.authorChang, Anna M
dc.contributor.authorPearson, Claire
dc.contributor.authorPeak, David A
dc.contributor.authorMerchant, Roland C
dc.contributor.authorDomeier, Robert M
dc.contributor.authorRathlev, Niels K
dc.contributor.authorO'Neil, Brian J
dc.contributor.authorSanchez, Leon D
dc.contributor.authorBruce, Steven E
dc.contributor.authorPietrzak, Robert H
dc.contributor.authorJoormann, Jutta
dc.contributor.authorBarch, Deanna M
dc.contributor.authorPizzagalli, Diego A
dc.contributor.authorSmoller, Jordan W
dc.contributor.authorLuna, Beatriz
dc.contributor.authorHarte, Steven E
dc.contributor.authorElliott, James M
dc.contributor.authorKessler, Ronald C
dc.contributor.authorRessler, Kerry J
dc.contributor.authorKoenen, Karestan C
dc.contributor.authorLyons, Michael S
dc.date.accessioned2022-12-16T16:30:38Z
dc.date.available2022-12-16T16:30:38Z
dc.date.issued2022-09-23
dc.identifier.citationPunches BE, Stolz U, Freiermuth CE, Ancona RM, McLean SA, House SL, Beaudoin FL, An X, Stevens JS, Zeng D, Neylan TC, Clifford GD, Jovanovic T, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Kurz MC, Gentile NT, McGrath ME, Hudak LA, Pascual JL, Seamon MJ, Harris E, Chang AM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sanchez LD, Bruce SE, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Smoller JW, Luna B, Harte SE, Elliott JM, Kessler RC, Ressler KJ, Koenen KC, Lyons MS. Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study. PLoS One. 2022 Sep 23;17(9):e0273378. doi: 10.1371/journal.pone.0273378. PMID: 36149896; PMCID: PMC9506640.en_US
dc.identifier.eissn1932-6203
dc.identifier.doi10.1371/journal.pone.0273378en_US
dc.identifier.pmid36149896
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51475
dc.description.abstractObjective: Whether short-term, low-potency opioid prescriptions for acute pain lead to future at-risk opioid use remains controversial and inadequately characterized. Our objective was to measure the association between emergency department (ED) opioid analgesic exposure after a physical, trauma-related event and subsequent opioid use. We hypothesized ED opioid analgesic exposure is associated with subsequent at-risk opioid use. Methods: Participants were enrolled in AURORA, a prospective cohort study of adult patients in 29 U.S., urban EDs receiving care for a traumatic event. Exclusion criteria were hospital admission, persons reporting any non-medical opioid use (e.g., opioids without prescription or taking more than prescribed for euphoria) in the 30 days before enrollment, and missing or incomplete data regarding opioid exposure or pain. We used multivariable logistic regression to assess the relationship between ED opioid exposure and at-risk opioid use, defined as any self-reported non-medical opioid use after initial ED encounter or prescription opioid use at 3-months. Results: Of 1441 subjects completing 3-month follow-up, 872 participants were included for analysis. At-risk opioid use occurred within 3 months in 33/620 (5.3%, CI: 3.7,7.4) participants without ED opioid analgesic exposure; 4/16 (25.0%, CI: 8.3, 52.6) with ED opioid prescription only; 17/146 (11.6%, CI: 7.1, 18.3) with ED opioid administration only; 12/90 (13.3%, CI: 7.4, 22.5) with both. Controlling for clinical factors, adjusted odds ratios (aORs) for at-risk opioid use after ED opioid exposure were: ED prescription only: 4.9 (95% CI 1.4, 17.4); ED administration for analgesia only: 2.0 (CI 1.0, 3.8); both: 2.8 (CI 1.2, 6.5). Conclusions: ED opioids were associated with subsequent at-risk opioid use within three months in a geographically diverse cohort of adult trauma patients. This supports need for prospective studies focused on the long-term consequences of ED opioid analgesic exposure to estimate individual risk and guide therapeutic decision-making.en_US
dc.language.isoenen_US
dc.relation.ispartofPLoS Oneen_US
dc.relation.urlhttps://doi.org/10.1371/journal.pone.0273378en_US
dc.rightsCopyright: © 2022 Punches et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.; Attribution 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectOpioidsen_US
dc.subjectCritical care and emergency medicineen_US
dc.subjectPainen_US
dc.subjectTraumatic injuryen_US
dc.subjectAnalgesicsen_US
dc.subjectAuroraen_US
dc.subjectMedical risk factorsen_US
dc.subjectPatientsen_US
dc.titlePredicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA studyen_US
dc.typeJournal Articleen_US
dc.source.journaltitlePloS one
dc.source.volume17
dc.source.issue9
dc.source.beginpagee0273378
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalPloS one
refterms.dateFOA2022-12-16T16:30:38Z
dc.contributor.departmentEmergency Medicineen_US


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Copyright: © 2022 Punches et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.; Attribution 4.0 International
Except where otherwise noted, this item's license is described as Copyright: © 2022 Punches et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.; Attribution 4.0 International