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    Microglia are SYK of Aβ and cell debris

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    Authors
    Schafer, Dorothy P
    Stillman, Jacob M
    Student Authors
    Jacob Stillman
    Academic Program
    Neuroscience
    UMass Chan Affiliations
    Brudnick Neuropsychiatric Research Institute
    Morningside Graduate School of Biomedical Sciences, Neuroscience Program
    Neurobiology
    Schafer Lab
    Document Type
    Journal Article
    Publication Date
    2022-10-27
    
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    Link to Full Text
    https://doi.org/10.1016/j.cell.2022.09.043
    Abstract
    During neurodegenerative disease, resident CNS macrophages termed "microglia" assume a neuroprotective role and engulf toxic protein aggregates and cell debris. In this issue of Cell, two groups independently show how spleen tyrosine kinase (SYK) acts downstream of microglial surface receptors to propagate this neuroprotective program in vivo.
    Source
    Schafer DP, Stillman JM. Microglia are SYK of Aβ and cell debris. Cell. 2022 Oct 27;185(22):4043-4045. doi: 10.1016/j.cell.2022.09.043. PMID: 36306731.
    DOI
    10.1016/j.cell.2022.09.043
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/51504
    PubMed ID
    36306731
    Rights
    Copyright © 2022 Elsevier Inc. All rights reserved.
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cell.2022.09.043
    Scopus Count
    Collections
    Morningside GSBS Scholarly Publications
    Neurobiology Student Publications
    Neurobiology Faculty Publications

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