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Student Authors
Jacob StillmanAcademic Program
NeuroscienceUMass Chan Affiliations
Brudnick Neuropsychiatric Research InstituteMorningside Graduate School of Biomedical Sciences
Neurobiology
Schafer Lab
Document Type
Journal ArticlePublication Date
2022-10-27
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Show full item recordAbstract
During neurodegenerative disease, resident CNS macrophages termed "microglia" assume a neuroprotective role and engulf toxic protein aggregates and cell debris. In this issue of Cell, two groups independently show how spleen tyrosine kinase (SYK) acts downstream of microglial surface receptors to propagate this neuroprotective program in vivo.Source
Schafer DP, Stillman JM. Microglia are SYK of Aβ and cell debris. Cell. 2022 Oct 27;185(22):4043-4045. doi: 10.1016/j.cell.2022.09.043. PMID: 36306731.DOI
10.1016/j.cell.2022.09.043Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51504PubMed ID
36306731Rights
Copyright © 2022 Elsevier Inc. All rights reserved.ae974a485f413a2113503eed53cd6c53
10.1016/j.cell.2022.09.043