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dc.contributor.authorPichardo, Margaret S
dc.contributor.authorEsserman, Denise
dc.contributor.authorFerrucci, Leah M
dc.contributor.authorMolina, Yamile
dc.contributor.authorChlebowski, Rowan T
dc.contributor.authorPan, Kathy
dc.contributor.authorGarcia, David O
dc.contributor.authorLane, Dorothy S
dc.contributor.authorShadyab, Aladdin H
dc.contributor.authorLopez-Pentecost, Melissa
dc.contributor.authorLuo, Juhua
dc.contributor.authorKato, Ikuko
dc.contributor.authorSpringfield, Sparkle
dc.contributor.authorRosal, Milagros C
dc.contributor.authorBea, Jennifer W
dc.contributor.authorCespedes Feliciano, Elizabeth M
dc.contributor.authorQi, Lihong
dc.contributor.authorNassir, Rami
dc.contributor.authorSnetselaar, Linda
dc.contributor.authorManson, JoAnn
dc.contributor.authorBird, Chloe
dc.contributor.authorIrwin, Melinda L
dc.date.accessioned2023-01-03T15:26:02Z
dc.date.available2023-01-03T15:26:02Z
dc.date.issued2022-08-23
dc.identifier.citationPichardo MS, Esserman D, Ferrucci LM, Molina Y, Chlebowski RT, Pan K, Garcia DO, Lane DS, Shadyab AH, Lopez-Pentecost M, Luo J, Kato I, Springfield S, Rosal MC, Bea JW, Cespedes Feliciano EM, Qi L, Nassir R, Snetselaar L, Manson J, Bird C, Irwin ML. Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity-related cancer risk and mortality in Black and Latina Women's Health Initiative participants. Cancer. 2022 Oct;128(20):3630-3640. doi: 10.1002/cncr.34428. Epub 2022 Aug 23. PMID: 35996861.en_US
dc.identifier.eissn1097-0142
dc.identifier.doi10.1002/cncr.34428en_US
dc.identifier.pmid35996861
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51508
dc.description.abstractBackground: Although adherence to the American Cancer Society (ACS) Guidelines on Nutrition and Physical Activity for Cancer Prevention associates with lower risk of obesity-related cancer (ORC) incidence and mortality, evidence in Black and Latina women is limited. This association was examined in Black and Latina participants in the Women's Health Initiative (WHI). Methods: Semi-Markov multistate model examined the association between ACS guideline adherence and ORC incidence and mortality in the presence of competing events, combined and separately, for 9301 Black and 4221 Latina postmenopausal women. Additionally, ACS guideline adherence was examined in a subset of less common ORCs and potential effect modification by neighborhood socioeconomic status and smoking. Results: Over a median of 11.1, 12.5, and 3.7 years of follow-up for incidence, nonconditional mortality, and conditional mortality, respectively, 1191 ORCs (Black/Latina women: 841/269), 1970 all-cause deaths (Black/Latina women: 1576/394), and 341 ORC-related deaths (Black/Latina women: 259/82) were observed. Higher ACS guideline adherence was associated with lower ORC incidence for both Black (cause-specific hazard ratio [CSHR]highvs.low : 0.72; 95% CI, 0.55-0.94) and Latina (CSHRhighvs.low : 0.58, 95% CI, 0.36-0.93) women; but not conditional all-cause mortality (Black hazard ratio [HR]highvs.low : 0.86; 95% CI, 0.53-1.39; Latina HRhighvs.low : 0.81; 95% CI, 0.32-2.06). Higher adherence was associated with lower incidence of less common ORC (Ptrend = .025), but conditional mortality events were limited. Adherence and ORC-specific deaths were not associated and there was no evidence of effect modification. Conclusions: Adherence to the ACS guidelines was associated with lower risk of ORCs and less common ORCs but was not for conditional ORC-related mortality. Lay summary: Evidence on the association between the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and cancer remains scarce for women of color. Adherence to the guidelines and risk of developing one of 13 obesity-related cancers among Black and Latina women in the Women's Health Initiative was examined. Women who followed the lifestyle guidelines had 28% to 42% lower risk of obesity-related cancer. These findings support public health interventions to reduce growing racial/ethnic disparities in obesity-related cancers.en_US
dc.language.isoenen_US
dc.relation.ispartofCanceren_US
dc.relation.urlhttps://doi.org/10.1002/cncr.34428en_US
dc.rights© 2022 American Cancer Society.en_US
dc.subjectBlack/African Americanen_US
dc.subjectHispanic/Latinaen_US
dc.subjectcancer risken_US
dc.subjectlifestyle guidelinesen_US
dc.subjectmortalityen_US
dc.subjectobesityen_US
dc.titleAdherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity-related cancer risk and mortality in Black and Latina Women's Health Initiative participantsen_US
dc.typeJournal Articleen_US
dc.source.journaltitleCancer
dc.source.volume128
dc.source.issue20
dc.source.beginpage3630
dc.source.endpage3640
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalCancer
dc.contributor.departmentPopulation and Quantitative Health Sciencesen_US
dc.contributor.departmentPrevention Research Centeren_US


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