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    How do I implement an outpatient program for the administration of convalescent plasma for COVID-19?

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    Authors
    Bloch, Evan M
    Tobian, Aaron A R
    Shoham, Shmuel
    Hanley, Daniel F
    Gniadek, Thomas J
    Cachay, Edward R
    Meisenberg, Barry R
    Kafka, Kimberly
    Marshall, Christi
    Heath, Sonya L
    Shenoy, Aarthi
    Paxton, James H
    Levine, Adam
    Forthal, Donald
    Fukuta, Yuriko
    Huaman, Moises A
    Ziman, Alyssa
    Adamski, Jill
    Gerber, Jonathan
    Cruser, Daniel
    Kassaye, Seble G
    Mosnaim, Giselle S
    Patel, Bela
    Metcalf, Ryan A
    Anjan, Shweta
    Reisler, Ronald B
    Yarava, Anusha
    Lane, Karen
    McBee, Nichol
    Gawad, Amy
    Raval, Jay S
    Zand, Martin
    Abinante, Matthew
    Broderick, Patrick B
    Casadevall, Arturo
    Sullivan, David
    Gebo, Kelly A
    Show allShow less
    UMass Chan Affiliations
    Medicine
    Document Type
    Journal Article
    Publication Date
    2022-04-04
    Keywords
    COVID-19
    COVID-19 serotherapy
    ambulatory care
    antibodies
    blood transfusion
    monoclonal
    plasma
    
    Metadata
    Show full item record
    Link to Full Text
    https://doi.org/10.1111/trf.16871
    Abstract
    Convalescent plasma, collected from donors who have recovered from a pathogen of interest, has been used to treat infectious diseases, particularly in times of outbreak, when alternative therapies were unavailable. The COVID-19 pandemic revived interest in the use of convalescent plasma. Large observational studies and clinical trials that were executed during the pandemic provided insight into how to use convalescent plasma, whereby high levels of antibodies against the pathogen of interest and administration early within the time course of the disease are critical for optimal therapeutic effect. Several studies have shown outpatient administration of COVID-19 convalescent plasma (CCP) to be both safe and effective, preventing clinical progression in patients when administered within the first week of COVID-19. The United States Food and Drug Administration expanded its emergency use authorization (EUA) to allow for the administration of CCP in an outpatient setting in December 2021, at least for immunocompromised patients or those on immunosuppressive therapy. Outpatient transfusion of CCP and infusion of monoclonal antibody therapies for a highly transmissible infectious disease introduces nuanced challenges related to infection prevention. Drawing on our experiences with the clinical and research use of CCP, we describe the logistical considerations and workflow spanning procurement of qualified products, infrastructure, staffing, transfusion, and associated management of adverse events. The purpose of this description is to facilitate the efforts of others intent on establishing outpatient transfusion programs for CCP and other antibody-based therapies.
    Source
    Bloch EM, Tobian AAR, Shoham S, Hanley DF, Gniadek TJ, Cachay ER, Meisenberg BR, Kafka K, Marshall C, Heath SL, Shenoy A, Paxton JH, Levine A, Forthal D, Fukuta Y, Huaman MA, Ziman A, Adamski J, Gerber J, Cruser D, Kassaye SG, Mosnaim GS, Patel B, Metcalf RA, Anjan S, Reisler RB, Yarava A, Lane K, McBee N, Gawad A, Raval JS, Zand M, Abinante M, Broderick PB, Casadevall A, Sullivan D, Gebo KA. How do I implement an outpatient program for the administration of convalescent plasma for COVID-19? Transfusion. 2022 May;62(5):933-941. doi: 10.1111/trf.16871. Epub 2022 Apr 4. PMID: 35352362; PMCID: PMC9086144.
    DOI
    10.1111/trf.16871
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/51540
    PubMed ID
    35352362
    Rights
    © 2022 AABB.
    ae974a485f413a2113503eed53cd6c53
    10.1111/trf.16871
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