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dc.contributor.authorMcElroy, Abigail
dc.contributor.authorSena-Esteves, Miguel
dc.contributor.authorArjomandnejad, Motahareh
dc.contributor.authorKeeler, Allison M
dc.contributor.authorGray-Edwards, Heather L
dc.date.accessioned2023-01-24T13:36:23Z
dc.date.available2023-01-24T13:36:23Z
dc.date.issued2022-09-16
dc.identifier.citationMcElroy A, Sena-Esteves M, Arjomandnejad M, Keeler AM, Gray-Edwards HL. Redosing Adeno-Associated Virus Gene Therapy to the Central Nervous System. Hum Gene Ther. 2022 Sep;33(17-18):889-892. doi: 10.1089/hum.2022.170. PMID: 36074937.en_US
dc.identifier.eissn1557-7422
dc.identifier.doi10.1089/hum.2022.170en_US
dc.identifier.pmid36074937
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51575
dc.description.abstractAdeno-associated virus (AAV)-mediated gene therapies have provided promising treatments for numerous neurological disorders. Redosing of AAV to the central nervous system (CNS) is an attractive research area due to both the somewhat immunologically privileged status of the CNS as well as the possibility of reduced glial transgene expression over time following a single injection. Continued study of the immune responses to both intraparenchymal and intra-CSF delivery of AAV mediated gene therapies, as well as the continued study of immunosuppressive regimens, could allow for eventual redosing in patients.en_US
dc.language.isoenen_US
dc.relation.ispartofHuman Gene Therapyen_US
dc.relation.urlhttps://doi.org/10.1089/hum.2022.170en_US
dc.subjectAAVen_US
dc.subjectcentral nervous systemen_US
dc.subjectgene therapyen_US
dc.subjectredosingen_US
dc.titleRedosing Adeno-Associated Virus Gene Therapy to the Central Nervous Systemen_US
dc.typeJournal Articleen_US
dc.source.journaltitleHuman gene therapy
dc.source.volume33
dc.source.issue17-18
dc.source.beginpage889
dc.source.endpage892
dc.source.countryUnited States
dc.identifier.journalHuman gene therapy
dc.contributor.departmentHorae Gene Therapy Centeren_US
dc.contributor.departmentLi Weibo Institute for Rare Diseases Researchen_US
dc.contributor.departmentNeurologyen_US
dc.contributor.departmentPediatricsen_US
dc.contributor.departmentRadiologyen_US


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