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    Differential association of baseline body weight and body-weight loss with neurological deficits, histology, and death after repetitive closed head traumatic brain injury

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    Authors
    Kahriman, Aydan
    Bouley, James
    Bosco, Daryl A
    Shazeeb, Mohammed Salman
    Henninger, Nils
    UMass Chan Affiliations
    Neurology
    Psychiatry
    Radiology
    Document Type
    Journal Article
    Publication Date
    2021-12-29
    Keywords
    Animal model
    Behavior
    Body weight
    Histology
    Seizures
    Traumatic brain injury
    
    Metadata
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    Link to Full Text
    https://doi.org/10.1016/j.neulet.2021.136430
    Abstract
    Clinical observations indicate that body weight (BW) extremes are associated with worse outcome after traumatic brain injury (TBI); yet, it is uncertain whether the baseline BW (bBW) may affect outcome after mouse TBI. We retrospectively analyzed 129 similarly aged (9-12 weeks) male C57BL6/J mice that were subjected to repetitive closed head TBI (rTBI) using an established weight drop paradigm as well as 55 sham injured mice. We sought to determine whether the bBW as well as the post-TBI weight relative to baseline (%BW) were associated with a variety of post-rTBI outcomes, including acute model complications (skull fractures and macroscopic hemorrhage), impact seizures, return of the righting reflex (RR), the neurological severity score (NSS), post-rTBI BW-change, and 28-day mortality. In a subset of rTBI mice, we also assessed for potential associations between the bBW and %BW and performance in the novel object recognition (NOR) task and various histological outcomes at 28 days. We found no association between the bBW with acute model complications, impact seizure burden, RR, NSS, and NOR performance at 28 days, as well as cerebral microbleed burden, presence of hyperphosphorylated tau, and TDP-43 pathology after rTBI. However, a higher bBW was associated with a longer time to first impact seizure, a greater microglial activation, astrocytosis, and neuronal loss in the injured cerebral cortex at 28 days. A greater %BW-loss was associated with a shorter impact seizure-free survival, longer time to return of the righting reflex, greater neurological deficit severity as assessed by the NSS and NOR, and worse mortality. On multiple linear regression there was no independent association of the %BW-loss with neuronal loss and neuroinflammation after adjustment for the bBW. These observations indicate that the bBW and %BW-loss may be important biological variables in certain experimental mouse TBI investigations, depending on the outcome measures of interest.
    Source
    Kahriman A, Bouley J, Bosco DA, Shazeeb MS, Henninger N. Differential association of baseline body weight and body-weight loss with neurological deficits, histology, and death after repetitive closed head traumatic brain injury. Neurosci Lett. 2022 Feb 6;771:136430. doi: 10.1016/j.neulet.2021.136430. Epub 2021 Dec 29. PMID: 34973374; PMCID: PMC8821174.
    DOI
    10.1016/j.neulet.2021.136430
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/51581
    PubMed ID
    34973374
    Rights
    Copyright © 2021 Elsevier B.V. All rights reserved.
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neulet.2021.136430
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