A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma
Authors
Ardisson Korat, Andres VChiu, Yu-Han
Bertrand, Kimberly A
Zhang, Shumin
Epstein, Mara M
Rosner, Bernard A
Chiuve, Stephanie
Campos, Hannia
Giovannucci, Edward L
Chavarro, Jorge E
Birmann, Brenda M
Document Type
Journal ArticlePublication Date
2022-10-18Keywords
Red blood cell membrane fatty acidsepidemiology
etiology
non-Hodgkin lymphoma
polyunsaturated fatty acids
prospective
UMCCTS funding
Metadata
Show full item recordAbstract
Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses' Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03-1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23-4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.Source
Ardisson Korat AV, Chiu YH, Bertrand KA, Zhang S, Epstein MM, Rosner BA, Chiuve S, Campos H, Giovannucci EL, Chavarro JE, Birmann BM. A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma. Leuk Lymphoma. 2022 Dec;63(14):3351-3361. doi: 10.1080/10428194.2022.2131419. Epub 2022 Oct 18. PMID: 36255154; PMCID: PMC9877158.DOI
10.1080/10428194.2022.2131419Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51639PubMed ID
36255154Funding and Acknowledgements
This work was supported by the [American Cancer Society] under [Research Scholar Grant RSG-11-020-01-CNE], by grants from the [National Institutes of Health] under grants [UM1 CA186107]; [P01 CA87969]; [R01 CA49449]; [U01 CA167552]; [R01 CA149445]; [R01 CA09812]; [U54 CA155626]; [P30 DK46200]; [KL2 TR001455 (to MME)], and [T32 CA009001 (to AVAK)] and the American Heart Association [grant 834106 to Y-HC].ae974a485f413a2113503eed53cd6c53
10.1080/10428194.2022.2131419