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dc.contributor.authorDavis, Julie E
dc.contributor.authorHarkey, Matthew S
dc.contributor.authorLiu, Shao-Hsien
dc.contributor.authorLapane, Kate L
dc.contributor.authorPrice, Lori Lyn
dc.contributor.authorLu, Bing
dc.contributor.authorLo, Grace H
dc.contributor.authorEaton, Charles B
dc.contributor.authorBarbe, Mary F
dc.contributor.authorMcAlindon, Timothy E
dc.contributor.authorDriban, Jeffrey B
dc.date.accessioned2023-03-03T16:33:59Z
dc.date.available2023-03-03T16:33:59Z
dc.date.issued2019-07-25
dc.identifier.citationDavis JE, Harkey MS, Liu SH, Lapane K, Price LL, Lu B, Lo GH, Eaton CB, Barbe MF, McAlindon TE, Driban JB. Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative. ACR Open Rheumatol. 2019 Jul 25;1(6):359-364. doi: 10.1002/acr2.11058. PMID: 31777814; PMCID: PMC6857962.en_US
dc.identifier.eissn2578-5745
dc.identifier.doi10.1002/acr2.11058en_US
dc.identifier.pmid31777814
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51745
dc.description.abstractObjective: To determine if people with incident accelerated knee osteoarthritis (AKOA) were more likely to receive a pharmacological treatment or arthroscopic knee surgery than those with typical knee osteoarthritis (KOA) or no KOA. Methods: We conducted a nested cohort study using data from baseline and the first 8 years of the Osteoarthritis Initiative. Eligible participants had no radiographic KOA at baseline (Kellgren-Lawrence [KL] < 2). We classified three groups using KL grades: 1) AKOA: knee progressed to advanced-stage KOA (KL 3/4) in 4 years or less, 2) typical KOA: knee increased in KL grade by 8 years (excluding AKOA), and 3) No KOA: no change in KL grade by 8 years. The outcome was self-reported arthroscopic knee surgery or a pharmacological treatment option: nonsteroidal anti-inflammatory drugs (NSAIDs), hyaluronic acid injections, intra-articular corticosteroid injections, or prescription analgesics. Between-group differences in therapeutic use were evaluated with Chi-square tests. Results: Adults who developed AKOA (n = 92) were more likely to report arthroscopic knee surgery (AKOA: 32%, KOA [n = 380]: 8%, no KOA [n = 875]: 3%; P < 0.001), hyaluronic acid injections (AKOA: 10%, KOA: 4%, no KOA: 1%; P < 0.001), intra-articular corticosteroid injections (AKOA: 30%, KOA: 7%, no KOA: 4%; P < 0.001), and NSAID use (over the counter: AKOA: 65%, KOA: 48%, and no KOA: 46%; P = 0.003; prescription: AKOA: 61%, KOA: 43%, no KOA: 41%; P = 0.002). Conclusion: Adults with AKOA are more likely to receive pharmacological treatment or arthroscopic knee surgery than their peers. Adults with AKOA are an important patient population that is understudied in clinical research despite their use of greater health care resources.en_US
dc.language.isoenen_US
dc.relation.ispartofACR Open Rheumatologyen_US
dc.relation.urlhttps://doi.org/10.1002/acr2.11058en_US
dc.rights© 2019 The Authors. ACR Open Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectUMCCTS fundingen_US
dc.titleAdults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiativeen_US
dc.typeJournal Articleen_US
dc.source.journaltitleACR open rheumatology
dc.source.volume1
dc.source.issue6
dc.source.beginpage359
dc.source.endpage364
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalACR open rheumatology
refterms.dateFOA2023-03-03T16:34:00Z
dc.contributor.departmentPopulation and Quantitative Health Sciencesen_US


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© 2019 The Authors. ACR Open Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Except where otherwise noted, this item's license is described as © 2019 The Authors. ACR Open Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.