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dc.contributor.authorShields, Alicia
dc.contributor.authorAmcheslavsky, Alla
dc.contributor.authorBrown, Elizabeth
dc.contributor.authorLee, Tom V
dc.contributor.authorNie, Yingchao
dc.contributor.authorTanji, Takahiro
dc.contributor.authorIp, Y Tony
dc.contributor.authorBergmann, Andreas
dc.date.accessioned2023-03-07T19:19:45Z
dc.date.available2023-03-07T19:19:45Z
dc.date.issued2022-05-17
dc.identifier.citationShields A, Amcheslavsky A, Brown E, Lee TV, Nie Y, Tanji T, Ip YT, Bergmann A. Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila. Cell Rep. 2022 May 17;39(7):110817. doi: 10.1016/j.celrep.2022.110817. PMID: 35584678; PMCID: PMC9211775.en_US
dc.identifier.eissn2211-1247
dc.identifier.doi10.1016/j.celrep.2022.110817en_US
dc.identifier.pmid35584678
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51750
dc.description.abstractDrosophila Toll-1 and all mammalian Toll-like receptors regulate innate immunity. However, the functions of the remaining eight Toll-related proteins in Drosophila are not fully understood. Here, we show that Drosophila Toll-9 is necessary and sufficient for a special form of compensatory proliferation after apoptotic cell loss (undead apoptosis-induced proliferation [AiP]). Mechanistically, for AiP, Toll-9 interacts with Toll-1 to activate the intracellular Toll-1 pathway for nuclear translocation of the NF-κB-like transcription factor Dorsal, which induces expression of the pro-apoptotic genes reaper and hid. This activity contributes to the feedback amplification loop that operates in undead cells. Given that Toll-9 also functions in loser cells during cell competition, we define a general role of Toll-9 in cellular stress situations leading to the expression of pro-apoptotic genes that trigger apoptosis and apoptosis-induced processes such as AiP. This work identifies conceptual similarities between cell competition and AiP.en_US
dc.language.isoenen_US
dc.relation.ispartofCell Reportsen_US
dc.relation.urlhttps://doi.org/10.1016/j.celrep.2022.110817en_US
dc.rightsCopyright 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCP: Cell biologyen_US
dc.subjectDrosophilaen_US
dc.subjectToll-1en_US
dc.subjectToll-9en_US
dc.subjectamplification loopen_US
dc.subjectapoptosis-induced proliferationen_US
dc.subjecthiden_US
dc.subjectnuclear translocation of dorsalen_US
dc.subjectreaperen_US
dc.subjectundead cellsen_US
dc.subjectUMCCTS fundingen_US
dc.titleToll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophilaen_US
dc.typeJournal Articleen_US
dc.source.journaltitleCell reports
dc.source.volume39
dc.source.issue7
dc.source.beginpage110817
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalCell reports
refterms.dateFOA2023-03-07T19:19:46Z
dc.contributor.departmentMolecular, Cell and Cancer Biologyen_US
dc.contributor.departmentProgram in Molecular Medicineen_US


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Copyright 2022 The Author(s). 
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as Copyright 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).