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dc.contributor.advisorElinor Karlssonen_US
dc.contributor.authorMorrill, Kathleen
dc.date.accessioned2023-03-13T15:35:29Z
dc.date.available2023-03-13T15:35:29Z
dc.date.issued2023-02-08
dc.identifier.doi10.13028/eda7-rd18en_US
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51797
dc.description.abstractMounting genomic evidence suggests that biological contributions to psychiatric disorder susceptibility are genetically complex, environmentally mediated, and highly comorbid. By paralleling human initiatives, I propose that comparative genomics in the domestic dog offers informational and translational utility to investigations of such complex conditions. Dogs present problematic behaviors with ostensible similarity to human disorders, such as separation anxiety and compulsive behaviors. As behavior played a major role in dog evolution, canine genomes may be enriched for common genetic variants underlying many behaviors. Breeds represent a distillation of diversity in appearance and behavior, but there has been limited success in linking the latter to genes using only pedigreed dogs. The genomes of “mutts” present a natural experiment in genome-wide admixture, which I leverage to map high-dimensional phenotypes across thousands of pet dogs. While I find that most behavioral differences are heritable, especially functional behaviors characteristic of major lineages, I also show that breed alone is an unreliable and confounded predictor of dog behavior. By intersecting genomic studies in people and dogs, this work supplies a roadmap for discerning and ranking cross-species relevance for a wide array of canine and human phenotypes, including psychiatric conditions.en_US
dc.language.isoen_USen_US
dc.publisherUMass Chan Medical Schoolen_US
dc.rights© 2023 Morrillen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectgeneticsen_US
dc.subjectgenomicsen_US
dc.subjectanimal modelen_US
dc.subjectdogen_US
dc.subjectCanis lupus familiarisen_US
dc.subjectdomesticationen_US
dc.subjectbehavioren_US
dc.subjectpsychiatric disordersen_US
dc.subjectbreeden_US
dc.subjectGWASen_US
dc.subjectcomparative geneticsen_US
dc.titleThe Genomics of Canine Behavior and its Comparative Relevance to Human Neuropsychiatric Conditionsen_US
dc.typeDoctoral Dissertationen_US
refterms.dateFOA2023-03-13T15:35:30Z
atmire.contributor.authoremailkathleen.morrill@umassmed.eduen_US
dc.contributor.departmentMorningside Graduate School of Biomedical Sciencesen_US
dc.contributor.departmentProgram in Bioinformatics and Integrative Biologyen_US
dc.description.thesisprogramNeuroscienceen_US
dc.identifier.orcid0000-0002-9139-453Xen_US


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