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dc.contributor.authorXu, Xiaowen
dc.contributor.authorSkelly, Jordan D
dc.contributor.authorSong, Jie
dc.date.accessioned2023-03-13T20:33:00Z
dc.date.available2023-03-13T20:33:00Z
dc.date.issued2023-01-06
dc.identifier.citationXu X, Skelly JD, Song J. Chemically Crosslinked Amphiphilic Degradable Shape Memory Polymer Nanocomposites with Readily Tuned Physical, Mechanical, and Biological Properties. ACS Appl Mater Interfaces. 2023 Jan 18;15(2):2693-2704. doi: 10.1021/acsami.2c19441. Epub 2023 Jan 6. PMID: 36607181.en_US
dc.identifier.eissn1944-8252
dc.identifier.doi10.1021/acsami.2c19441en_US
dc.identifier.pmid36607181
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51799
dc.description.abstractFacile surgical delivery and stable fixation of synthetic scaffolds play roles just as critically as degradability and bioactivity in ensuring successful scaffold-guided tissue regeneration. Properly engineered shape memory polymers (SMPs) may meet these challenges. Polyhedral oligomeric silsesquioxanes (POSSs) can be covalently integrated with urethane-crosslinked polylactide (PLA) to give high-strength, degradable SMPs around physiological temperatures. To explore their potential for guided bone regeneration, here we tune their hydrophilicity, degradability, cytocompatibility, and osteoconductivity/osteoinductivity by crosslinking star-branched POSS-PLA with hydrophilic polyethylene glycol diisocyanates of different lengths and up to 60 wt % hydroxyapatite (HA). The composites exhibit high compliance, toughness, up to gigapascal storage moduli, and excellent shape recovery (>95%) at safe triggering temperatures. Water swelling ratios and hydrolytic degradation rates positively correlated with the hydrophilic crosslinker lengths, while the negative impact of degradation on the proliferation and osteogenesis of bone marrow stromal cells was mitigated with HA incorporation. Macroporous composites tailored for a rat femoral segmental defect were fabricated, and their ability to stably retain and sustainedly release recombinant osteogenic bone morphogenetic protein-2 and support cell attachment and osteogenesis was demonstrated. These properties combined make these amphiphilic osteoconductive degradable SMPs promising candidates as next-generation synthetic bone grafts.en_US
dc.language.isoenen_US
dc.relation.ispartofACS Applied Materials & Interfacesen_US
dc.relation.urlhttps://doi.org/10.1021/acsami.2c19441en_US
dc.subjecthydroxyapatiteen_US
dc.subjectmacroporous scaffolden_US
dc.subjectosteogenesisen_US
dc.subjectpolyhedral oligomeric silsesquioxaneen_US
dc.subjectshape memory polymeren_US
dc.titleChemically Crosslinked Amphiphilic Degradable Shape Memory Polymer Nanocomposites with Readily Tuned Physical, Mechanical, and Biological Propertiesen_US
dc.typeJournal Articleen_US
dc.source.journaltitleACS applied materials & interfaces
dc.source.volume15
dc.source.issue2
dc.source.beginpage2693
dc.source.endpage2704
dc.source.countryUnited States
dc.identifier.journalACS applied materials & interfaces
dc.contributor.departmentBiochemistry and Molecular Biotechnologyen_US
dc.contributor.departmentOrthopedics and Physical Rehabilitationen_US


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