Differential vulnerability of thalamic nuclei in multiple sclerosis
Authors
Blyau, SimonKoubiyr, Ismail
Saranathan, Manojkumar
Coupé, Pierrick
Deloire, Mathilde
Charré-Morin, Julie
Saubusse, Aurore
Zhang, Bei
Rutt, Brian
Dousset, Vincent
Brochet, Bruno
Ruet, Aurélie
Tourdias, Thomas
UMass Chan Affiliations
RadiologyDocument Type
Journal ArticlePublication Date
2022-08-12
Metadata
Show full item recordAbstract
Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.Source
Blyau S, Koubiyr I, Saranathan M, Coupé P, Deloire M, Charré-Morin J, Saubusse A, Zhang B, Rutt B, Dousset V, Brochet B, Ruet A, Tourdias T. Differential vulnerability of thalamic nuclei in multiple sclerosis. Mult Scler. 2023 Feb;29(2):295-300. doi: 10.1177/13524585221114247. Epub 2022 Aug 12. PMID: 35959722.DOI
10.1177/13524585221114247Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51818PubMed ID
35959722ae974a485f413a2113503eed53cd6c53
10.1177/13524585221114247