Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood
Authors
Ziobrowski, H NHolt-Gosselin, B
Petukhova, M V
King, A J
Lee, S
House, S L
Beaudoin, F L
An, X
Stevens, J S
Zeng, D
Neylan, T C
Clifford, G D
Linnstaedt, S D
Germine, L T
Bollen, K A
Rauch, S L
Haran, John P
Storrow, A B
Lewandowski, C
Musey, P I
Hendry, P L
Sheikh, S
Jones, C W
Punches, B E
Kurz, M C
Swor, R A
Hudak, L A
Pascual, J L
Seamon, M J
Harris, E
Pearson, C
Merchant, R C
Domeier, R M
Rathlev, N K
O'Neil, B J
Sergot, P
Sanchez, L D
Bruce, S E
Miller, M W
Pietrzak, R H
Joormann, J
Barch, D M
Pizzagalli, D A
Harte, S E
Elliott, J M
Ressler, K J
McLean, S A
Koenen, K C
Kessler, R C
UMass Chan Affiliations
Emergency MedicineDocument Type
Journal ArticlePublication Date
2023-01-10
Metadata
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Aims: Childhood adversities (CAs) predict heightened risks of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) among people exposed to adult traumatic events. Identifying which CAs put individuals at greatest risk for these adverse posttraumatic neuropsychiatric sequelae (APNS) is important for targeting prevention interventions. Methods: Data came from n = 999 patients ages 18-75 presenting to 29 U.S. emergency departments after a motor vehicle collision (MVC) and followed for 3 months, the amount of time traditionally used to define chronic PTSD, in the Advancing Understanding of Recovery After Trauma (AURORA) study. Six CA types were self-reported at baseline: physical abuse, sexual abuse, emotional abuse, physical neglect, emotional neglect and bullying. Both dichotomous measures of ever experiencing each CA type and numeric measures of exposure frequency were included in the analysis. Risk ratios (RRs) of these CA measures as well as complex interactions among these measures were examined as predictors of APNS 3 months post-MVC. APNS was defined as meeting self-reported criteria for either PTSD based on the PTSD Checklist for DSM-5 and/or MDE based on the PROMIS Depression Short-Form 8b. We controlled for pre-MVC lifetime histories of PTSD and MDE. We also examined mediating effects through peritraumatic symptoms assessed in the emergency department and PTSD and MDE assessed in 2-week and 8-week follow-up surveys. Analyses were carried out with robust Poisson regression models. Results: Most participants (90.9%) reported at least rarely having experienced some CA. Ever experiencing each CA other than emotional neglect was univariably associated with 3-month APNS (RRs = 1.31-1.60). Each CA frequency was also univariably associated with 3-month APNS (RRs = 1.65-2.45). In multivariable models, joint associations of CAs with 3-month APNS were additive, with frequency of emotional abuse (RR = 2.03; 95% CI = 1.43-2.87) and bullying (RR = 1.44; 95% CI = 0.99-2.10) being the strongest predictors. Control variable analyses found that these associations were largely explained by pre-MVC histories of PTSD and MDE. Conclusions: Although individuals who experience frequent emotional abuse and bullying in childhood have a heightened risk of experiencing APNS after an adult MVC, these associations are largely mediated by prior histories of PTSD and MDE.Source
Ziobrowski HN, Holt-Gosselin B, Petukhova MV, King AJ, Lee S, House SL, Beaudoin FL, An X, Stevens JS, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Kurz MC, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Pearson C, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Miller MW, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Harte SE, Elliott JM, Ressler KJ, McLean SA, Koenen KC, Kessler RC. Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood. Epidemiol Psychiatr Sci. 2023 Jan 10;32:e1. doi: 10.1017/S2045796022000798. PMID: 36624694; PMCID: PMC9879881.DOI
10.1017/S2045796022000798Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51865PubMed ID
36624694Rights
Copyright © The Author(s), 2023. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution- NonCommercial-NoDerivatives licence (http:// creativecommons.org/licenses/by-nc-nd/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and/or adaptation of the article.; Attribution-NonCommercial-NoDerivatives 4.0 InternationalDistribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1017/S2045796022000798
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Except where otherwise noted, this item's license is described as Copyright © The Author(s), 2023. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution- NonCommercial-NoDerivatives licence (http:// creativecommons.org/licenses/by-nc-nd/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and/or adaptation of the article.; Attribution-NonCommercial-NoDerivatives 4.0 International