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dc.contributor.authorBeaudoin, Francesca L
dc.contributor.authorAn, Xinming
dc.contributor.authorBasu, Archana
dc.contributor.authorJi, Yinyao
dc.contributor.authorLiu, Mochuan
dc.contributor.authorKessler, Ronald C
dc.contributor.authorDoughtery, Robert F
dc.contributor.authorZeng, Donglin
dc.contributor.authorBollen, Kenneth A
dc.contributor.authorHouse, Stacey L
dc.contributor.authorStevens, Jennifer S
dc.contributor.authorNeylan, Thomas C
dc.contributor.authorClifford, Gari D
dc.contributor.authorJovanovic, Tanja
dc.contributor.authorLinnstaedt, Sarah D
dc.contributor.authorGermine, Laura T
dc.contributor.authorRauch, Scott L
dc.contributor.authorHaran, John P
dc.contributor.authorStorrow, Alan B
dc.contributor.authorLewandowski, Christopher
dc.contributor.authorMusey, Paul I
dc.contributor.authorHendry, Phyllis L
dc.contributor.authorSheikh, Sophia
dc.contributor.authorJones, Christopher W
dc.contributor.authorPunches, Brittany E
dc.contributor.authorKurz, Michael C
dc.contributor.authorSwor, Robert A
dc.contributor.authorMurty, Vishnu P
dc.contributor.authorMcGrath, Meghan E
dc.contributor.authorHudak, Lauren A
dc.contributor.authorPascual, Jose L
dc.contributor.authorDatner, Elizabeth M
dc.contributor.authorChang, Anna M
dc.contributor.authorPearson, Claire
dc.contributor.authorPeak, David A
dc.contributor.authorMerchant, Roland C
dc.contributor.authorDomeier, Robert M
dc.contributor.authorRathlev, Niels K
dc.contributor.authorNeil, Brian J O'
dc.contributor.authorSergot, Paulina
dc.contributor.authorSanchez, Leon D
dc.contributor.authorBruce, Steven E
dc.contributor.authorBaker, Justin T
dc.contributor.authorJoormann, Jutta
dc.contributor.authorMiller, Mark W
dc.contributor.authorPietrzak, Robert H
dc.contributor.authorBarch, Deanna M
dc.contributor.authorPizzagalli, Diego A
dc.contributor.authorSheridan, John F
dc.contributor.authorSmoller, Jordan W
dc.contributor.authorHarte, Steven E
dc.contributor.authorElliott, James M
dc.contributor.authorKoenen, Karestan C
dc.contributor.authorRessler, Kerry J
dc.contributor.authorMcLean, Samuel A
dc.date.accessioned2023-03-22T19:38:49Z
dc.date.available2023-03-22T19:38:49Z
dc.date.issued2023-01-07
dc.identifier.citationBeaudoin FL, An X, Basu A, Ji Y, Liu M, Kessler RC, Doughtery RF, Zeng D, Bollen KA, House SL, Stevens JS, Neylan TC, Clifford GD, Jovanovic T, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Kurz MC, Swor RA, Murty VP, McGrath ME, Hudak LA, Pascual JL, Datner EM, Chang AM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, Neil BJO, Sergot P, Sanchez LD, Bruce SE, Baker JT, Joormann J, Miller MW, Pietrzak RH, Barch DM, Pizzagalli DA, Sheridan JF, Smoller JW, Harte SE, Elliott JM, Koenen KC, Ressler KJ, McLean SA. Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort. Transl Psychiatry. 2023 Jan 7;13(1):4. doi: 10.1038/s41398-022-02289-y. PMID: 36609484; PMCID: PMC9823011.en_US
dc.identifier.eissn2158-3188
dc.identifier.doi10.1038/s41398-022-02289-yen_US
dc.identifier.pmid36609484
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51868
dc.description.abstractThe authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along with associations within and between trajectories. APNS across all ten symptom domains were common in the first two months after trauma. Many risk factors and associations with high symptom burden trajectories were shared across domains. Both across and within traditional diagnostic boundaries, APNS trajectory intercepts, and slopes were substantially correlated. Across all domains, symptom severity in the immediate aftermath of trauma (trajectory intercepts) had the greatest influence on the outcome. An interactive data visualization tool was developed to allow readers to explore relationships of interest between individual characteristics, symptom trajectories, and traditional outcomes ( http://itr.med.unc.edu/aurora/parcoord/ ). Individuals presenting to the ED after MVC commonly experience a broad constellation of adverse posttraumatic symptoms. Many risk factors for diverse APNS are shared. Individuals diagnosed with a single traditional outcome should be screened for others. The utility of multidimensional categorizations that characterize individuals across traditional diagnostic domains should be explored.en_US
dc.language.isoenen_US
dc.relation.ispartofTranslational Psychiatryen_US
dc.relation.urlhttps://doi.org/10.1038/s41398-022-02289-yen_US
dc.rightsOpen Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http:// creativecommons.org/licenses/by/4.0/. © The Author(s) 2023en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDepressionen_US
dc.subjectPathogenesisen_US
dc.titleUse of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohorten_US
dc.typeJournal Articleen_US
dc.source.journaltitleTranslational psychiatry
dc.source.volume13
dc.source.issue1
dc.source.beginpage4
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalTranslational psychiatry
refterms.dateFOA2023-03-22T19:38:50Z
dc.contributor.departmentEmergency Medicineen_US


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Open Access: This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly
from the copyright holder. To view a copy of this license, visit http://
creativecommons.org/licenses/by/4.0/.
© The Author(s) 2023
Except where otherwise noted, this item's license is described as Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http:// creativecommons.org/licenses/by/4.0/. © The Author(s) 2023