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dc.contributor.authorMetheny, Leland
dc.contributor.authorCallander, Natalie S
dc.contributor.authorHall, Aric C
dc.contributor.authorZhang, Mei-Jei
dc.contributor.authorBo-Subait, Khalid
dc.contributor.authorWang, Hai-Lin
dc.contributor.authorAgrawal, Vaibhav
dc.contributor.authorAl-Homsi, A Samer
dc.contributor.authorAssal, Amer
dc.contributor.authorBacher, Ulrike
dc.contributor.authorBeitinjaneh, Amer
dc.contributor.authorBejanyan, Nelli
dc.contributor.authorBhatt, Vijaya Raj
dc.contributor.authorBredeson, Chris
dc.contributor.authorByrne, Michael
dc.contributor.authorCairo, Mitchell
dc.contributor.authorCerny, Jan
dc.contributor.authorDeFilipp, Zachariah
dc.contributor.authorPerez, Miguel Angel Diaz
dc.contributor.authorFreytes, César O
dc.contributor.authorGanguly, Siddhartha
dc.contributor.authorGrunwald, Michael R
dc.contributor.authorHashmi, Shahrukh
dc.contributor.authorHildebrandt, Gerhard C
dc.contributor.authorInamoto, Yoshihiro
dc.contributor.authorKanakry, Christopher G
dc.contributor.authorKharfan-Dabaja, Mohamed A
dc.contributor.authorLazarus, Hillard M
dc.contributor.authorLee, Jong Wook
dc.contributor.authorNathan, Sunita
dc.contributor.authorNishihori, Taiga
dc.contributor.authorOlsson, Richard F
dc.contributor.authorRingdén, Olov
dc.contributor.authorRizzieri, David
dc.contributor.authorSavani, Bipin N
dc.contributor.authorSavoie, Mary Lynn
dc.contributor.authorSeo, Sachiko
dc.contributor.authorvan der Poel, Marjolein
dc.contributor.authorVerdonck, Leo F
dc.contributor.authorWagner, John L
dc.contributor.authorYared, Jean A
dc.contributor.authorHourigan, Christopher S
dc.contributor.authorKebriaei, Partow
dc.contributor.authorLitzow, Mark
dc.contributor.authorSandmaier, Brenda M
dc.contributor.authorSaber, Wael
dc.contributor.authorWeisdorf, Daniel
dc.contributor.authorde Lima, Marcos
dc.date.accessioned2023-03-24T17:42:53Z
dc.date.available2023-03-24T17:42:53Z
dc.date.issued2021-08-21
dc.identifier.citationMetheny L, Callander NS, Hall AC, Zhang MJ, Bo-Subait K, Wang HL, Agrawal V, Al-Homsi AS, Assal A, Bacher U, Beitinjaneh A, Bejanyan N, Bhatt VR, Bredeson C, Byrne M, Cairo M, Cerny J, DeFilipp Z, Perez MAD, Freytes CO, Ganguly S, Grunwald MR, Hashmi S, Hildebrandt GC, Inamoto Y, Kanakry CG, Kharfan-Dabaja MA, Lazarus HM, Lee JW, Nathan S, Nishihori T, Olsson RF, Ringdén O, Rizzieri D, Savani BN, Savoie ML, Seo S, van der Poel M, Verdonck LF, Wagner JL, Yared JA, Hourigan CS, Kebriaei P, Litzow M, Sandmaier BM, Saber W, Weisdorf D, de Lima M. Allogeneic Transplantation to Treat Therapy-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Adults. Transplant Cell Ther. 2021 Nov;27(11):923.e1-923.e12. doi: 10.1016/j.jtct.2021.08.010. Epub 2021 Aug 21. PMID: 34428556; PMCID: PMC9064046.en_US
dc.identifier.eissn2666-6367
dc.identifier.doi10.1016/j.jtct.2021.08.010en_US
dc.identifier.pmid34428556
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51889
dc.description.abstractPatients who develop therapy-related myeloid neoplasm, either myelodysplastic syndrome (t-MDS) or acute myelogenous leukemia (t-AML), have a poor prognosis. An earlier Center for International Blood and Marrow Transplant Research (CIBMTR) analysis of 868 allogeneic hematopoietic cell transplantations (allo-HCTs) performed between 1990 and 2004 showed a 5-year overall survival (OS) and disease-free survival (DFS) of 22% and 21%, respectively. Modern supportive care, graft-versus-host disease prophylaxis, and reduced-intensity conditioning (RIC) regimens have led to improved outcomes. Therefore, the CIBMTR analyzed 1531 allo-HCTs performed in adults with t-MDS (n = 759) or t-AML (n = 772) between and 2000 and 2014. The median age was 59 years (range, 18 to 74 years) for the patients with t-MDS and 52 years (range, 18 to 77 years) for those with t-AML. Twenty-four percent of patients with t-MDS and 11% of those with t-AML had undergone a previous autologous (auto-) HCT. A myeloablative conditioning (MAC) regimen was used in 49% of patients with t-MDS and 61% of patients with t-AML. Nonrelapse mortality at 5 years was 34% (95% confidence interval [CI], 30% to 37%) for patients with t-MDS and 34% (95% CI, 30% to 37%) for those with t-AML. Relapse rates at 5 years in the 2 groups were 46% (95% CI, 43% to 50%) and 43% (95% CI, 40% to 47%). Five-year OS and DFS were 27% (95% CI, 23% to 31%) and 19% (95% CI, 16% to 23%), respectively, for patients with t-MDS and 25% (95% CI, 22% to 28%) and 23% (95% CI, 20% to 26%), respectively, for those with t-AML. In multivariate analysis, OS and DFS were significantly better in young patients with low-risk t-MDS and those with t-AML undergoing HCT with MAC while in first complete remission, but worse for those with previous auto-HCT, higher-risk cytogenetics or Revised International Prognostic Scoring System score, and a partially matched unrelated donor. Relapse remains the major cause of treatment failure, with little improvement seen over the past 2 decades. These data mandate caution when recommending allo-HCT in these conditions and indicate the need for more effective antineoplastic approaches before and after allo-HCT.en_US
dc.language.isoenen_US
dc.relation.ispartofTransplantation and Cellular Therapyen_US
dc.relation.urlhttps://doi.org/10.1016/j.jtct.2021.08.010en_US
dc.rightsCopyright © 2021. Published by Elsevier Inc.en_US
dc.subjectAcute myelogenous leukemiaen_US
dc.subjectAllogeneic transplantationen_US
dc.subjectMyelodysplasiaen_US
dc.titleAllogeneic Transplantation to Treat Therapy-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Adultsen_US
dc.typeJournal Articleen_US
dc.source.journaltitleTransplantation and cellular therapy
dc.source.volume27
dc.source.issue11
dc.source.beginpage923.e1
dc.source.endpage923.e12
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalTransplantation and cellular therapy
dc.contributor.departmentMedicineen_US


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