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    Gliotransmission and adenosine signaling promote axon regeneration

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    Authors
    Wang, Fei
    Ruppell, Kendra Takle
    Zhou, Songlin
    Qu, Yun
    Gong, Jiaxin
    Shang, Ye
    Wu, Jinglin
    Liu, Xin
    Diao, Wenlin
    Li, Yi
    Xiang, Yang
    Show allShow less
    Student Authors
    Kendra Takle Ruppell
    Ye Shang
    Fei Wang
    Academic Program
    Neuroscience
    UMass Chan Affiliations
    Neurobiology
    Yang Xiang Lab
    Document Type
    Journal Article
    Publication Date
    2023-04-06
    Keywords
    gliotransmission
    mammalian CNS repair
    neuronal subtype-specific axon regeneration
    purinergic signaling
    
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    Link to Full Text
    https://doi.org/10.1016/j.devcel.2023.03.007
    Abstract
    How glia control axon regeneration remains incompletely understood. Here, we investigate glial regulation of regenerative ability differences of closely related Drosophila larval sensory neuron subtypes. Axotomy elicits Ca2+ signals in ensheathing glia, which activates regenerative neurons through the gliotransmitter adenosine and mounts axon regenerative programs. However, non-regenerative neurons do not respond to glial stimulation or adenosine. Such neuronal subtype-specific responses result from specific expressions of adenosine receptors in regenerative neurons. Disrupting gliotransmission impedes axon regeneration of regenerative neurons, and ectopic adenosine receptor expression in non-regenerative neurons suffices to activate regenerative programs and induce axon regeneration. Furthermore, stimulating gliotransmission or activating the mammalian ortholog of Drosophila adenosine receptors in retinal ganglion cells (RGCs) promotes axon regrowth after optic nerve crush in adult mice. Altogether, our findings demonstrate that gliotransmission orchestrates neuronal subtype-specific axon regeneration in Drosophila and suggest that targeting gliotransmission or adenosine signaling is a strategy for mammalian central nervous system repair.
    Source
    Wang F, Ruppell KT, Zhou S, Qu Y, Gong J, Shang Y, Wu J, Liu X, Diao W, Li Y, Xiang Y. Gliotransmission and adenosine signaling promote axon regeneration. Dev Cell. 2023 Apr 24;58(8):660-676.e7. doi: 10.1016/j.devcel.2023.03.007. Epub 2023 Apr 6. PMID: 37028426.
    DOI
    10.1016/j.devcel.2023.03.007
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/52026
    PubMed ID
    37028426
    Rights
    Copyright © 2023 Elsevier Inc. All rights reserved.
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.devcel.2023.03.007
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