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    The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells

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    Authors
    Tran, Khanh-Van
    Gealekman, Olga
    Frontini, Andrea
    Zingaretti, Maria Cristina
    Morroni, Manrico
    Giordano, Antonio
    Smorlesi, Arianna
    Perugini, Jessica
    De Matteis, Rita
    Sbarbati, Andrea
    Corvera, Silvia
    Cinti, Saverio
    Show allShow less
    Student Authors
    Khanh-Van Tran
    Academic Program
    MD/PhD
    UMass Chan Affiliations
    Morningside Graduate School of Biomedical Sciences
    Program in Molecular Medicine
    T.H. Chan School of Medicine
    Document Type
    Journal Article
    Publication Date
    2012-02-08
    
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    Link to Full Text
    https://doi.org/10.1016/j.cmet.2012.01.008
    Abstract
    Adipose tissue expansion involves the enlargement of existing adipocytes, the formation of new cells from committed preadipocytes, and the coordinated development of the tissue vascular network. Here we find that murine endothelial cells (ECs) of classic white and brown fat depots share ultrastructural characteristics with pericytes, which are pluripotent and can potentially give rise to preadipocytes. Lineage tracing experiments using the VE-cadherin promoter reveal localization of reporter genes in ECs and also in preadipocytes and adipocytes of white and brown fat depots. Furthermore, capillary sprouts from human adipose tissue, which have predominantly EC characteristics, are found to express Zfp423, a recently identified marker of preadipocyte determination. In response to PPARγ activation, endothelial characteristics of sprouting cells are progressively lost, and cells form structurally and biochemically defined adipocytes. Together these data support an endothelial origin of murine and human adipocytes, suggesting a model for how adipogenesis and angiogenesis are coordinated during adipose tissue expansion.
    Source
    Tran KV, Gealekman O, Frontini A, Zingaretti MC, Morroni M, Giordano A, Smorlesi A, Perugini J, De Matteis R, Sbarbati A, Corvera S, Cinti S. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 2012 Feb 8;15(2):222-9. doi: 10.1016/j.cmet.2012.01.008. PMID: 22326223; PMCID: PMC3278718.
    DOI
    10.1016/j.cmet.2012.01.008
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/52040
    PubMed ID
    22326223
    Rights
    Copyright © 2012 Elsevier Inc. All rights reserved.
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cmet.2012.01.008
    Scopus Count
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    T.H. Chan School of Medicine Student Publications
    Morningside GSBS Scholarly Publications

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