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dc.contributor.authorTran, Khanh-Van
dc.contributor.authorGealekman, Olga
dc.contributor.authorFrontini, Andrea
dc.contributor.authorZingaretti, Maria Cristina
dc.contributor.authorMorroni, Manrico
dc.contributor.authorGiordano, Antonio
dc.contributor.authorSmorlesi, Arianna
dc.contributor.authorPerugini, Jessica
dc.contributor.authorDe Matteis, Rita
dc.contributor.authorSbarbati, Andrea
dc.contributor.authorCorvera, Silvia
dc.contributor.authorCinti, Saverio
dc.date.accessioned2023-05-08T14:44:53Z
dc.date.available2023-05-08T14:44:53Z
dc.date.issued2012-02-08
dc.identifier.citationTran KV, Gealekman O, Frontini A, Zingaretti MC, Morroni M, Giordano A, Smorlesi A, Perugini J, De Matteis R, Sbarbati A, Corvera S, Cinti S. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 2012 Feb 8;15(2):222-9. doi: 10.1016/j.cmet.2012.01.008. PMID: 22326223; PMCID: PMC3278718.en_US
dc.identifier.eissn1932-7420
dc.identifier.doi10.1016/j.cmet.2012.01.008en_US
dc.identifier.pmid22326223
dc.identifier.urihttp://hdl.handle.net/20.500.14038/52040
dc.description.abstractAdipose tissue expansion involves the enlargement of existing adipocytes, the formation of new cells from committed preadipocytes, and the coordinated development of the tissue vascular network. Here we find that murine endothelial cells (ECs) of classic white and brown fat depots share ultrastructural characteristics with pericytes, which are pluripotent and can potentially give rise to preadipocytes. Lineage tracing experiments using the VE-cadherin promoter reveal localization of reporter genes in ECs and also in preadipocytes and adipocytes of white and brown fat depots. Furthermore, capillary sprouts from human adipose tissue, which have predominantly EC characteristics, are found to express Zfp423, a recently identified marker of preadipocyte determination. In response to PPARγ activation, endothelial characteristics of sprouting cells are progressively lost, and cells form structurally and biochemically defined adipocytes. Together these data support an endothelial origin of murine and human adipocytes, suggesting a model for how adipogenesis and angiogenesis are coordinated during adipose tissue expansion.en_US
dc.language.isoenen_US
dc.relation.ispartofCell Metabolismen_US
dc.relation.urlhttps://doi.org/10.1016/j.cmet.2012.01.008en_US
dc.rightsCopyright © 2012 Elsevier Inc. All rights reserved.en_US
dc.titleThe vascular endothelium of the adipose tissue gives rise to both white and brown fat cellsen_US
dc.typeJournal Articleen_US
dc.source.journaltitleCell metabolism
dc.source.volume15
dc.source.issue2
dc.source.beginpage222
dc.source.endpage9
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalCell metabolism
dc.contributor.departmentMorningside Graduate School of Biomedical Sciencesen_US
dc.contributor.departmentProgram in Molecular Medicineen_US
dc.contributor.departmentT.H. Chan School of Medicineen_US
dc.contributor.studentKhanh-Van Tranen_US
dc.description.thesisprogramMD/PhDen_US


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