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dc.contributor.authorLucas, Bronwyn A
dc.date.accessioned2023-07-20T19:32:33Z
dc.date.available2023-07-20T19:32:33Z
dc.date.issued2023-06-04
dc.identifier.citationLucas BA. Visualizing everything, everywhere, all at once: Cryo-EM and the new field of structureomics. Curr Opin Struct Biol. 2023 Jun 4;81:102620. doi: 10.1016/j.sbi.2023.102620. Epub ahead of print. PMID: 37279614.en_US
dc.identifier.eissn1879-033X
dc.identifier.doi10.1016/j.sbi.2023.102620en_US
dc.identifier.pmid37279614
dc.identifier.urihttp://hdl.handle.net/20.500.14038/52333
dc.description.abstractTwenty years ago, the release of the first draft of the human genome sequence instigated a paradigm shift in genomics and molecular biology. Arguably, structural biology is entering an analogous era, with availability of an experimentally determined or predicted molecular model for almost every protein-coding gene from many genomes-producing a reference "structureome". Structural predictions require experimental validation and not all proteins conform to a single structure, making any reference structureome necessarily incomplete. Despite these limitations, a reference structureome can be used to characterize cell state in more detail than by quantifying sequence or expression levels alone. Cryogenic electron microscopy (cryo-EM) is a method that can generate atomic resolution views of molecules and cells frozen in place. In this perspective I consider how emerging cryo-EM methods are contributing to the new field of structureomics.en_US
dc.language.isoenen_US
dc.relation.ispartofCurrent Opinion in Structural Biologyen_US
dc.relation.urlhttps://doi.org/10.1016/j.sbi.2023.102620en_US
dc.rights© 2023 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleVisualizing everything, everywhere, all at once: Cryo-EM and the new field of structureomicsen_US
dc.typeJournal Articleen_US
dc.source.journaltitleCurrent opinion in structural biology
dc.source.volume81
dc.source.beginpage102620
dc.source.endpage
dc.source.countryEngland
dc.identifier.journalCurrent opinion in structural biology
refterms.dateFOA2023-07-20T19:32:34Z
dc.contributor.departmentRNA Therapeutics Instituteen_US


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© 2023 The Author. Published by Elsevier Ltd. This is an
open access article under the CC BY license (http://creativecommons.
org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2023 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).