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dc.contributor.authorSoni, Apurv
dc.contributor.authorHerbert, Carly
dc.contributor.authorLin, Honghuang
dc.contributor.authorYan, Yi
dc.contributor.authorPretz, Caitlin
dc.contributor.authorStamegna, Pamela
dc.contributor.authorWang, Biqi
dc.contributor.authorOrwig, Taylor
dc.contributor.authorWright, Colton
dc.contributor.authorTarrant, Seanan
dc.contributor.authorBehar, Stephanie
dc.contributor.authorSuvarna, Thejas
dc.contributor.authorSchrader, Summer
dc.contributor.authorHarman, Emma
dc.contributor.authorNowak, Chris
dc.contributor.authorKheterpal, Vik
dc.contributor.authorRao, Lokinendi V
dc.contributor.authorCashman, Lisa
dc.contributor.authorOrvek, Elizabeth
dc.contributor.authorAyturk, Didem
dc.contributor.authorGibson, Laura L
dc.contributor.authorZai, Adrian
dc.contributor.authorWong, Steven
dc.contributor.authorLazar, Peter
dc.contributor.authorWang, Ziyue
dc.contributor.authorFilippaios, Andreas
dc.contributor.authorBarton, Bruce
dc.contributor.authorAchenbach, Chad J
dc.contributor.authorMurphy, Robert L
dc.contributor.authorRobinson, Matthew L
dc.contributor.authorManabe, Yukari C
dc.contributor.authorPandey, Shishir
dc.contributor.authorColubri, Andrés
dc.contributor.authorO'Connor, Laurel
dc.contributor.authorLemon, Stephenie C
dc.contributor.authorFahey, Nisha
dc.contributor.authorLuzuriaga, Katherine L
dc.contributor.authorHafer, Nathaniel
dc.contributor.authorRoth, Kristian
dc.contributor.authorLowe, Toby
dc.contributor.authorStenzel, Timothy
dc.contributor.authorHeetderks, William
dc.contributor.authorBroach, John
dc.contributor.authorMcManus, David D
dc.date.accessioned2023-08-15T19:58:39Z
dc.date.available2023-08-15T19:58:39Z
dc.date.issued2023-07-04
dc.identifier.citationSoni A, Herbert C, Lin H, Yan Y, Pretz C, Stamegna P, Wang B, Orwig T, Wright C, Tarrant S, Behar S, Suvarna T, Schrader S, Harman E, Nowak C, Kheterpal V, Rao LV, Cashman L, Orvek E, Ayturk D, Gibson L, Zai A, Wong S, Lazar P, Wang Z, Filippaios A, Barton B, Achenbach CJ, Murphy RL, Robinson ML, Manabe YC, Pandey S, Colubri A, O'Connor L, Lemon SC, Fahey N, Luzuriaga KL, Hafer N, Roth K, Lowe T, Stenzel T, Heetderks W, Broach J, McManus DD. Performance of Rapid Antigen Tests to Detect Symptomatic and Asymptomatic SARS-CoV-2 Infection : A Prospective Cohort Study. Ann Intern Med. 2023 Jul;176(7):975-982. doi: 10.7326/M23-0385. Epub 2023 Jul 4. PMID: 37399548; PMCID: PMC10321467.en_US
dc.identifier.eissn1539-3704
dc.identifier.doi10.7326/M23-0385en_US
dc.identifier.pmid37399548
dc.identifier.urihttp://hdl.handle.net/20.500.14038/52421
dc.description.abstractBackground: The performance of rapid antigen tests (Ag-RDTs) for screening asymptomatic and symptomatic persons for SARS-CoV-2 is not well established. Objective: To evaluate the performance of Ag-RDTs for detection of SARS-CoV-2 among symptomatic and asymptomatic participants. Design: This prospective cohort study enrolled participants between October 2021 and January 2022. Participants completed Ag-RDTs and reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 every 48 hours for 15 days. Setting: Participants were enrolled digitally throughout the mainland United States. They self-collected anterior nasal swabs for Ag-RDTs and RT-PCR testing. Nasal swabs for RT-PCR were shipped to a central laboratory, whereas Ag-RDTs were done at home. Participants: Of 7361 participants in the study, 5353 who were asymptomatic and negative for SARS-CoV-2 on study day 1 were eligible. In total, 154 participants had at least 1 positive RT-PCR result. Measurements: The sensitivity of Ag-RDTs was measured on the basis of testing once (same-day), twice (after 48 hours), and thrice (after a total of 96 hours). The analysis was repeated for different days past index PCR positivity (DPIPPs) to approximate real-world scenarios where testing initiation may not always coincide with DPIPP 0. Results were stratified by symptom status. Results: Among 154 participants who tested positive for SARS-CoV-2, 97 were asymptomatic and 57 had symptoms at infection onset. Serial testing with Ag-RDTs twice 48 hours apart resulted in an aggregated sensitivity of 93.4% (95% CI, 90.4% to 95.9%) among symptomatic participants on DPIPPs 0 to 6. When singleton positive results were excluded, the aggregated sensitivity on DPIPPs 0 to 6 for 2-time serial testing among asymptomatic participants was lower at 62.7% (CI, 57.0% to 70.5%), but it improved to 79.0% (CI, 70.1% to 87.4%) with testing 3 times at 48-hour intervals. Limitation: Participants tested every 48 hours; therefore, these data cannot support conclusions about serial testing intervals shorter than 48 hours. Conclusion: The performance of Ag-RDTs was optimized when asymptomatic participants tested 3 times at 48-hour intervals and when symptomatic participants tested 2 times separated by 48 hours. Primary funding source: National Institutes of Health RADx Tech program.en_US
dc.description.sponsorshipGrant Support: By the NIH RADx Tech program under grant 3U54HL143541-02S2 and NIH Clinical and Translational Science Award grant UL1TR001453.en_US
dc.language.isoenen_US
dc.relationThis article is based on a previously available preprint in medRxiv, https://doi.org/10.1101/2022.08.05.22278466en_US
dc.relation.ispartofAnnals of Internal Medicineen_US
dc.relation.urlhttps://doi.org/10.7326/m23-0385en_US
dc.subjectUMCCTS fundingen_US
dc.subjectSARS-CoV-2en_US
dc.subjectrapid antigen testsen_US
dc.titlePerformance of Rapid Antigen Tests to Detect Symptomatic and Asymptomatic SARS-CoV-2 Infection : A Prospective Cohort Studyen_US
dc.typeJournal Articleen_US
dc.source.journaltitleAnnals of internal medicine
dc.source.volume176
dc.source.issue7
dc.source.beginpage975
dc.source.endpage982
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalAnnals of internal medicine
dc.contributor.departmentCenter for Clinical and Translational Scienceen_US
dc.contributor.departmentEmergency Medicineen_US
dc.contributor.departmentMedicineen_US
dc.contributor.departmentMicrobiology and Physiological Systemsen_US
dc.contributor.departmentMorningside Graduate School of Biomedical Sciencesen_US
dc.contributor.departmentPediatricsen_US
dc.contributor.departmentPopulation and Quantitative Health Sciencesen_US
dc.contributor.departmentPrevention Research Centeren_US
dc.contributor.departmentProgram in Bioinformatics and Integrative Biologyen_US
dc.contributor.departmentProgram in Molecular Medicineen_US
dc.contributor.departmentBiostatistics and Health Services Researchen_US
dc.contributor.studentCarly Herbert


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