A Multisite Randomized Controlled Trial of Mindfulness-Based Stress Reduction in the Treatment of Posttraumatic Stress Disorder
AuthorsDavis, Lori L
Hamner, Mark B
Carmody, James F.
Rothbaum, Barbara O
Allen, Rebecca S
Southwick, Steven M
Bremner, James Douglas
UMass Chan AffiliationsPopulation and Quantitative Health Sciences
Document TypeJournal Article
MetadataShow full item record
AbstractObjective: Posttraumatic stress disorder (PTSD) is often difficult to treat, and many patients do not achieve full remission. Complementary and integrative health approaches, such as mindfulness meditation, are intended to be integrated with evidence-based treatment. This study examined the efficacy of mindfulness-based stress reduction (MBSR) in the treatment of PTSD in U.S. military veterans. Methods: Veterans with a diagnosis of PTSD (N=214) were randomly assigned to either 90-minute group MBSR or present-centered group therapy (PCGT) for eight weeks. Follow-up assessments were obtained at baseline and weeks 3, 6, 9 (primary endpoint), and 16. Results: Both the MBSR and PCGT groups achieved significant improvement in PTSD as measured by the Clinician-Administered PTSD Scale for DSM-IV (CAPS-IV), with no statistically significant differences between groups. However, compared with PCGT, the MBSR group showed a statistically significant improvement in PTSD on the self-reported PTSD Checklist for DSM-IV over the nine weeks. This difference was not maintained posttreatment, at week 16. Strengths of the study include its large sample size, multisite design, active control group, single-blind outcome ratings, fidelity monitoring, large minority representation, and randomized approach. The study was limited by its high attrition rate and low representation of women. Conclusion: Both MBSR and PCGT appear to have beneficial effects in treating PTSD in veterans, with greater improvement observed in self-reported PTSD symptoms in the MBSR group. No differences between groups were observed on the CAPS-IV scale.
SourceDavis LL, Whetsell C, Hamner MB, Carmody J, Rothbaum BO, Allen RS, Al Bartolucci ABPP, Southwick SM, Bremner JD. A Multisite Randomized Controlled Trial of Mindfulness-Based Stress Reduction in the Treatment of Posttraumatic Stress Disorder. Psychiatr Res Clin Pract. 2019 Oct 1;1(2):39-48. doi: 10.1176/appi.prcp.20180002. Epub 2018 Sep 13. PMID: 34113802; PMCID: PMC8189576.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/52537
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Except where otherwise noted, this item's license is described as © 2019 American Psychiatric Association This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.