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dc.contributor.authorHochbaum, Daniel R
dc.contributor.authorDubinsky, Alexandra C
dc.contributor.authorFarnsworth, Hannah C
dc.contributor.authorHulshof, Lauren
dc.contributor.authorKleinberg, Giona
dc.contributor.authorUrke, Amanda
dc.contributor.authorWang, Wengang
dc.contributor.authorHakim, Richard
dc.contributor.authorRobertson, Keira
dc.contributor.authorPark, Canaria
dc.contributor.authorSolberg, Alyssa
dc.contributor.authorYang, Yechan
dc.contributor.authorBaynard, Caroline
dc.contributor.authorNadaf, Naeem M
dc.contributor.authorBeron, Celia C
dc.contributor.authorGirasole, Allison E
dc.contributor.authorChantranupong, Lynne
dc.contributor.authorCortopassi, Marissa
dc.contributor.authorProuty, Shannon
dc.contributor.authorGeistlinger, Ludwig
dc.contributor.authorBanks, Alexander
dc.contributor.authorScanlan, Thomas
dc.contributor.authorGreenberg, Michael E
dc.contributor.authorBoulting, Gabriella L
dc.contributor.authorMacosko, Evan Z
dc.contributor.authorSabatini, Bernardo L
dc.date.accessioned2023-10-23T19:04:35Z
dc.date.available2023-10-23T19:04:35Z
dc.date.issued2023-08-10
dc.identifier.citationHochbaum DR, Dubinsky AC, Farnsworth HC, Hulshof L, Kleinberg G, Urke A, Wang W, Hakim R, Robertson K, Park C, Solberg A, Yang Y, Baynard C, Nadaf NM, Beron CC, Girasole AE, Chantranupong L, Cortopassi M, Prouty S, Geistlinger L, Banks A, Scanlan T, Greenberg ME, Boulting GL, Macosko EZ, Sabatini BL. Thyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive. bioRxiv [Preprint]. 2023 Aug 10:2023.08.10.552874. doi: 10.1101/2023.08.10.552874. PMID: 37609206; PMCID: PMC10441422.en_US
dc.identifier.doi10.1101/2023.08.10.552874en_US
dc.identifier.pmid37609206
dc.identifier.urihttp://hdl.handle.net/20.500.14038/52634
dc.descriptionThis article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.en_US
dc.description.abstractAnimals adapt to varying environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here we find that thyroid hormone- a prominent regulator of metabolism in many peripheral organs- activates cell-type specific transcriptional programs in anterior regions of cortex of adult mice via direct activation of thyroid hormone receptors. These programs are enriched for axon-guidance genes in glutamatergic projection neurons, synaptic regulators across both astrocytes and neurons, and pro-myelination factors in oligodendrocytes, suggesting widespread remodeling of cortical circuits. Indeed, whole-cell electrophysiology recordings revealed that thyroid hormone induces local transcriptional programs that rewire cortical neural circuits via pre-synaptic mechanisms, resulting in increased excitatory drive with a concomitant sensitization of recruited inhibition. We find that thyroid hormone bidirectionally regulates innate exploratory behaviors and that the transcriptionally mediated circuit changes in anterior cortex causally promote exploratory decision-making. Thus, thyroid hormone acts directly on adult cerebral cortex to coordinate exploratory behaviors with whole-body metabolic state.en_US
dc.language.isoenen_US
dc.relation.ispartofbioRxiven_US
dc.relation.urlhttps://doi.org/10.1101/2023.08.10.552874en_US
dc.rightsThe copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.en_US
dc.subjectNeuroscienceen_US
dc.subjectthyroid hormoneen_US
dc.subjectmetabolismen_US
dc.titleThyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive [preprint]en_US
dc.typePreprinten_US
dc.source.journaltitlebioRxiv : the preprint server for biology
dc.source.countryUnited States
dc.identifier.journalbioRxiv : the preprint server for biology
dc.contributor.departmentNeurobiologyen_US
dc.contributor.departmentBoulting Lab


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