Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics
Student AuthorsKathleen Morrill
UMass Chan AffiliationsMorningside Graduate School of Biomedical Sciences
Program in Bioinformatics and Integrative Biology
Document TypeJournal Article
MetadataShow full item record
AbstractDomestic dogs display a wide array of heritable behaviors that have intermediate genetic complexity thanks to a long history of human-influenced selection. Comparative genetics in dogs could address the scarcity of non-human neurogenetic systems relevant to human neuropsychiatric disorders, which are characterized by mental, emotional, and behavioral symptoms and involve vastly complex genetic and non-genetic risk factors. Our review describes the diverse behavioral "phenome" of domestic dogs, past and ongoing sources of behavioral selection, and the state of canine behavioral genetics. We highlight two naturally disordered behavioral domains that illustrate how dogs may prove useful as a comparative, forward neurogenetic system: canine age-related cognitive dysfunction, which can be examined more rapidly given the attenuated lifespan of dogs, and compulsive disorders, which may have genetic roots in purpose-bred behaviors. Growing community science initiatives aimed at the companion dog population will be well suited to investigating such complex behavioral phenotypes and offer a comparative resource that parallels human genomic initiatives in scale and dimensionality.
SourceMorrill K, Chen F, Karlsson E. Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics. Hum Genet. 2023 Aug;142(8):1231-1246. doi: 10.1007/s00439-023-02580-y. Epub 2023 Aug 14. PMID: 37578529.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/52650
Rights© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.