Show simple item record

dc.contributor.authorMorrill, Kathleen
dc.contributor.authorChen, Frances
dc.contributor.authorKarlsson, Elinor K
dc.date.accessioned2023-10-27T19:28:28Z
dc.date.available2023-10-27T19:28:28Z
dc.date.issued2023-08-14
dc.identifier.citationMorrill K, Chen F, Karlsson E. Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics. Hum Genet. 2023 Aug;142(8):1231-1246. doi: 10.1007/s00439-023-02580-y. Epub 2023 Aug 14. PMID: 37578529.en_US
dc.identifier.eissn1432-1203
dc.identifier.doi10.1007/s00439-023-02580-yen_US
dc.identifier.pmid37578529
dc.identifier.urihttp://hdl.handle.net/20.500.14038/52650
dc.description.abstractDomestic dogs display a wide array of heritable behaviors that have intermediate genetic complexity thanks to a long history of human-influenced selection. Comparative genetics in dogs could address the scarcity of non-human neurogenetic systems relevant to human neuropsychiatric disorders, which are characterized by mental, emotional, and behavioral symptoms and involve vastly complex genetic and non-genetic risk factors. Our review describes the diverse behavioral "phenome" of domestic dogs, past and ongoing sources of behavioral selection, and the state of canine behavioral genetics. We highlight two naturally disordered behavioral domains that illustrate how dogs may prove useful as a comparative, forward neurogenetic system: canine age-related cognitive dysfunction, which can be examined more rapidly given the attenuated lifespan of dogs, and compulsive disorders, which may have genetic roots in purpose-bred behaviors. Growing community science initiatives aimed at the companion dog population will be well suited to investigating such complex behavioral phenotypes and offer a comparative resource that parallels human genomic initiatives in scale and dimensionality.en_US
dc.language.isoenen_US
dc.relation.ispartofHuman Geneticsen_US
dc.relation.urlhttps://doi.org/10.1007/s00439-023-02580-yen_US
dc.rights© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.en_US
dc.titleComparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric geneticsen_US
dc.typeJournal Articleen_US
dc.source.journaltitleHuman genetics
dc.source.volume142
dc.source.issue8
dc.source.beginpage1231
dc.source.endpage1246
dc.source.countryGermany
dc.identifier.journalHuman genetics
dc.contributor.departmentMorningside Graduate School of Biomedical Sciencesen_US
dc.contributor.departmentProgram in Bioinformatics and Integrative Biologyen_US
dc.contributor.studentKathleen Morrill
dc.description.thesisprogramNeuroscience


This item appears in the following Collection(s)

Show simple item record