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dc.contributor.authorChu, Derek K
dc.contributor.authorChu, Alexandro W L
dc.contributor.authorRayner, Daniel G
dc.contributor.authorGuyatt, Gordon H
dc.contributor.authorYepes-Nuñez, Juan José
dc.contributor.authorGomez-Escobar, Luis
dc.contributor.authorPérez-Herrera, Lucia C
dc.contributor.authorDíaz Martinez, Juan Pablo
dc.contributor.authorBrignardello-Petersen, Romina
dc.contributor.authorSadeghirad, Behnam
dc.contributor.authorWong, Melanie M
dc.contributor.authorCeccacci, Renata
dc.contributor.authorZhao, Irene X
dc.contributor.authorBasmaji, John
dc.contributor.authorMacDonald, Margaret
dc.contributor.authorChu, Xiajing
dc.contributor.authorIslam, Nazmul
dc.contributor.authorGao, Ya
dc.contributor.authorIzcovich, Ariel
dc.contributor.authorAsiniwasis, Rachel N
dc.contributor.authorBoguniewicz, Mark
dc.contributor.authorDe Benedetto, Anna
dc.contributor.authorCapozza, Korey
dc.contributor.authorChen, Lina
dc.contributor.authorEllison, Kathy
dc.contributor.authorFrazier, Winfred T
dc.contributor.authorGreenhawt, Matthew
dc.contributor.authorHuynh, Joey
dc.contributor.authorLeBovidge, Jennifer
dc.contributor.authorLio, Peter A
dc.contributor.authorMartin, Stephen A
dc.contributor.authorO'Brien, Monica
dc.contributor.authorOng, Peck Y
dc.contributor.authorSilverberg, Jonathan I
dc.contributor.authorSpergel, Jonathan M
dc.contributor.authorSmith Begolka, Wendy
dc.contributor.authorWang, Julie
dc.contributor.authorWheeler, Kathryn E
dc.contributor.authorGardner, Donna D
dc.contributor.authorSchneider, Lynda
dc.date.accessioned2023-10-27T19:31:31Z
dc.date.available2023-10-27T19:31:31Z
dc.date.issued2023-09-05
dc.identifier.citationChu DK, Chu AWL, Rayner DG, Guyatt GH, Yepes-Nuñez JJ, Gomez-Escobar L, Pérez-Herrera LC, Díaz Martinez JP, Brignardello-Petersen R, Sadeghirad B, Wong MM, Ceccacci R, Zhao IX, Basmaji J, MacDonald M, Chu X, Islam N, Gao Y, Izcovich A, Asiniwasis RN, Boguniewicz M, De Benedetto A, Capozza K, Chen L, Ellison K, Frazier WT, Greenhawt M, Huynh J, LeBovidge J, Lio PA, Martin SA, O'Brien M, Ong PY, Silverberg JI, Spergel JM, Smith Begolka W, Wang J, Wheeler KE, Gardner DD, Schneider L. Topical treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trials. J Allergy Clin Immunol. 2023 Sep 5:S0091-6749(23)01113-2. doi: 10.1016/j.jaci.2023.08.030. Epub ahead of print. PMID: 37678572.en_US
dc.identifier.eissn1097-6825
dc.identifier.doi10.1016/j.jaci.2023.08.030en_US
dc.identifier.pmid37678572
dc.identifier.urihttp://hdl.handle.net/20.500.14038/52652
dc.description.abstractBackground: Atopic dermatitis (AD) is a common skin condition with multiple topical treatment options, but uncertain comparative effects. Objectives: We systematically synthesized the benefits and harms of AD prescription topical treatments. Methods: For the 2023 AAAAI/ACAAI JTFPP AD guidelines, we searched MEDLINE, EMBASE, CENTRAL, CINAHL, LILACS, ICTRP, and GREAT to September 5, 2022 for randomized trials addressing AD topical treatments. Paired reviewers independently screened records, extracted data, and assessed risk of bias. Random-effects network meta-analyses addressed AD severity, itch, sleep, AD-quality of life, flares, and harms. The GRADE approach informed certainty of evidence ratings. We classified topical corticosteroids (TCS) using seven classes-group 1 being most potent. OSF: https://osf.io/q5m6s. Results: 219 included trials (43,123 patients) evaluated 68 interventions. With high-certainty, pimecrolimus improved six of seven outcomes-among the best for two; high-dose tacrolimus (0.1%) improved five-among the best for two; low-dose tacrolimus (0.03%) improved five-among the best for one. With moderate-to-high certainty, group 5 TCS improved six-among the best for three; group 4 TCS and delgocitinib improved four-among the best for two; ruxolitinib improved four-among the best for one; group 1 TCS improved three-among the best for two. These interventions did not increase harms. Crisaborole and difamilast were intermediately effective, but uncertain harm. Topical antibiotics alone or in combination may be among the least effective. To maintain AD control, group 5 TCS were among the most effective, followed by tacrolimus and pimecrolimus. Conclusions: For individuals with AD, pimecrolimus, tacrolimus, and moderate-potency TCS are among the most effective in improving and maintaining multiple AD outcomes. Topical antibiotics may be among the least effective.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Allergy and Clinical Immunologyen_US
dc.relation.urlhttps://doi.org/10.1016/j.jaci.2023.08.030en_US
dc.rightsCopyright © 2023. Published by Elsevier Inc.en_US
dc.subjectGRADEen_US
dc.subjectadverse eventsen_US
dc.subjectatopic dermatitisen_US
dc.subjectcomparative effectsen_US
dc.subjectcrisaboroleen_US
dc.subjectdelgocitiniben_US
dc.subjectdifamilasten_US
dc.subjectdisease severityen_US
dc.subjecteczemaen_US
dc.subjectflares (exacerbations)en_US
dc.subjectinduction of remissionen_US
dc.subjectitchen_US
dc.subjectlotamilasten_US
dc.subjectmaintenance of remissionen_US
dc.subjectnetwork meta-analysisen_US
dc.subjectpatient-important outcomesen_US
dc.subjectpimecrolimusen_US
dc.subjectquality of lifeen_US
dc.subjectreactive vs proactive therapyen_US
dc.subjectroflumilasten_US
dc.subjectruxolitiniben_US
dc.subjectsleepen_US
dc.subjecttacrolimusen_US
dc.subjecttopical JAK inhibitorsen_US
dc.subjecttopical antibioticsen_US
dc.subjecttopical calcineurin inhibitorsen_US
dc.subjecttopical corticosteroidsen_US
dc.subjecttopical phosphodiesterase-4 (PDE-4) inhibitorsen_US
dc.subjecttopical treatmentsen_US
dc.titleTopical treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trialsen_US
dc.typeJournal Articleen_US
dc.source.journaltitleThe Journal of allergy and clinical immunology
dc.source.countryUnited States
dc.identifier.journalThe Journal of allergy and clinical immunology
dc.contributor.departmentFamily Medicine and Community Healthen_US


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