Long non-coding RNAs: definitions, functions, challenges and recommendations
Authors
Mattick, John SAmaral, Paulo P
Carninci, Piero
Carpenter, Susan
Chang, Howard Y
Chen, Ling-Ling
Chen, Runsheng
Dean, Caroline
Dinger, Marcel E
Fitzgerald, Katherine A
Gingeras, Thomas R
Guttman, Mitchell
Hirose, Tetsuro
Huarte, Maite
Johnson, Rory
Kanduri, Chandrasekhar
Kapranov, Philipp
Lawrence, Jeanne B
Lee, Jeannie T
Mendell, Joshua T
Mercer, Timothy R
Moore, Kathryn J
Nakagawa, Shinichi
Rinn, John L
Spector, David L
Ulitsky, Igor
Wan, Yue
Wilusz, Jeremy E
Wu, Mian
Document Type
Journal ArticlePublication Date
2023-01-03
Metadata
Show full item recordAbstract
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II and Pol III transcribed RNAs, and RNAs from processed introns. The various functions of lncRNAs and their many isoforms and interleaved relationships with other genes make lncRNA classification and annotation difficult. Most lncRNAs evolve more rapidly than protein-coding sequences, are cell type specific and regulate many aspects of cell differentiation and development and other physiological processes. Many lncRNAs associate with chromatin-modifying complexes, are transcribed from enhancers and nucleate phase separation of nuclear condensates and domains, indicating an intimate link between lncRNA expression and the spatial control of gene expression during development. lncRNAs also have important roles in the cytoplasm and beyond, including in the regulation of translation, metabolism and signalling. lncRNAs often have a modular structure and are rich in repeats, which are increasingly being shown to be relevant to their function. In this Consensus Statement, we address the definition and nomenclature of lncRNAs and their conservation, expression, phenotypic visibility, structure and functions. We also discuss research challenges and provide recommendations to advance the understanding of the roles of lncRNAs in development, cell biology and disease.Source
Mattick JS, Amaral PP, Carninci P, Carpenter S, Chang HY, Chen LL, Chen R, Dean C, Dinger ME, Fitzgerald KA, Gingeras TR, Guttman M, Hirose T, Huarte M, Johnson R, Kanduri C, Kapranov P, Lawrence JB, Lee JT, Mendell JT, Mercer TR, Moore KJ, Nakagawa S, Rinn JL, Spector DL, Ulitsky I, Wan Y, Wilusz JE, Wu M. Long non-coding RNAs: definitions, functions, challenges and recommendations. Nat Rev Mol Cell Biol. 2023 Jun;24(6):430-447. doi: 10.1038/s41580-022-00566-8. Epub 2023 Jan 3. PMID: 36596869; PMCID: PMC10213152.DOI
10.1038/s41580-022-00566-8Permanent Link to this Item
http://hdl.handle.net/20.500.14038/52661PubMed ID
36596869Rights
© 2023. Springer Nature Limited.ae974a485f413a2113503eed53cd6c53
10.1038/s41580-022-00566-8