Show simple item record

dc.contributor.authorCohen, Louis J
dc.contributor.authorHan, Sun M
dc.contributor.authorLau, Pearson
dc.contributor.authorGuisado, Daniela
dc.contributor.authorLiang, Yupu
dc.contributor.authorNakashige, Toshiki G
dc.contributor.authorAli, Thamina
dc.contributor.authorChiang, David
dc.contributor.authorRahman, Adeeb
dc.contributor.authorBrady, Sean F
dc.date.accessioned2023-11-07T20:34:34Z
dc.date.available2023-11-07T20:34:34Z
dc.date.issued2022-06-03
dc.identifier.citationCohen LJ, Han SM, Lau P, Guisado D, Liang Y, Nakashige TG, Ali T, Chiang D, Rahman A, Brady SF. Unraveling function and diversity of bacterial lectins in the human microbiome. Nat Commun. 2022 Jun 3;13(1):3101. doi: 10.1038/s41467-022-29949-3. PMID: 35661736; PMCID: PMC9166713.en_US
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-022-29949-3en_US
dc.identifier.pmid35661736
dc.identifier.urihttp://hdl.handle.net/20.500.14038/52707
dc.description.abstractThe mechanisms by which commensal organisms affect human physiology remain poorly understood. Lectins are non-enzymatic carbohydrate binding proteins that all organisms employ as part of establishing a niche, evading host-defenses and protecting against pathogens. Although lectins have been extensively studied in plants, bacterial pathogens and human immune cells for their role in disease pathophysiology and as therapeutics, the role of bacterial lectins in the human microbiome is largely unexplored. Here we report on the characterization of a lectin produced by a common human associated bacterium that interacts with myeloid cells in the blood and intestine. In mouse and cell-based models, we demonstrate that this lectin induces distinct immunologic responses in peripheral and intestinal leukocytes and that these responses are specific to monocytes, macrophages and dendritic cells. Our analysis of human microbiota sequencing data reveal thousands of unique sequences that are predicted to encode lectins, many of which are highly prevalent in the human microbiome yet completely uncharacterized. Based on the varied domain architectures of these lectins we predict they will have diverse effects on the human host. The systematic investigation of lectins in the human microbiome should improve our understanding of human health and provide new therapeutic opportunities.en_US
dc.language.isoenen_US
dc.relation.ispartofNature Communicationsen_US
dc.relation.urlhttps://doi.org/10.1038/s41467-022-29949-3en_US
dc.rightsOpen Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2022en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectComputational biology and bioinformaticsen_US
dc.subjectMicrobiologyen_US
dc.titleUnraveling function and diversity of bacterial lectins in the human microbiomeen_US
dc.typeJournal Articleen_US
dc.source.journaltitleNature communications
dc.source.volume13
dc.source.issue1
dc.source.beginpage3101
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.identifier.journalNature communications
refterms.dateFOA2023-11-07T20:34:35Z
dc.contributor.departmentMedicineen_US


Files in this item

Thumbnail
Name:
s41467-022-29949-3.pdf
Size:
2.584Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Open Access: This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.
© The Author(s) 2022
Except where otherwise noted, this item's license is described as Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2022