Show simple item record

dc.contributor.authorFarjo, Mireille
dc.contributor.authorKoelle, Katia
dc.contributor.authorMartin, Michael A
dc.contributor.authorGibson, Laura L
dc.contributor.authorWalden, Kimberly K O
dc.contributor.authorRendon, Gloria
dc.contributor.authorFields, Christopher J
dc.contributor.authorAlnaji, Fadi G
dc.contributor.authorGallagher, Nicholas
dc.contributor.authorLuo, Chun Huai
dc.contributor.authorMostafa, Heba H
dc.contributor.authorManabe, Yukari C
dc.contributor.authorPekosz, Andrew
dc.contributor.authorSmith, Rebecca L
dc.contributor.authorMcManus, David D
dc.contributor.authorBrooke, Christopher B
dc.date.accessioned2024-01-11T21:04:07Z
dc.date.available2024-01-11T21:04:07Z
dc.date.issued2024-01-04
dc.identifier.citationFarjo M, Koelle K, Martin MA, Gibson LL, Walden KKO, Rendon G, Fields CJ, Alnaji FG, Gallagher N, Luo CH, Mostafa HH, Manabe YC, Pekosz A, Smith RL, McManus DD, Brooke CB. Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection. J Virol. 2024 Jan 4:e0161823. doi: 10.1128/jvi.01618-23. Epub ahead of print. PMID: 38174928.en_US
dc.identifier.eissn1098-5514
dc.identifier.doi10.1128/jvi.01618-23en_US
dc.identifier.pmid38174928
dc.identifier.urihttp://hdl.handle.net/20.500.14038/52960
dc.description.abstractWe detail the within-host evolutionary dynamics of SARS-CoV-2 during acute infection in 31 individuals using daily longitudinal sampling. We characterized patterns of mutational accumulation for unvaccinated and vaccinated individuals, and observed that temporal variant dynamics in both groups were largely stochastic. Comparison of paired nasal and saliva samples also revealed significant genetic compartmentalization between tissue environments in multiple individuals. Our results demonstrate how selection, genetic drift, and spatial compartmentalization all play important roles in shaping the within-host evolution of SARS-CoV-2 populations during acute infection.en_US
dc.language.isoenen_US
dc.relationThis article is based on a previously available preprint in bioRxiv, https://doi.org/10.1101/2022.06.21.497047en_US
dc.relation.ispartofJournal of Virologyen_US
dc.relation.urlhttps://doi.org/10.1128/jvi.01618-23en_US
dc.subjectSARS-CoV-2en_US
dc.subjectgenetic compartmentalizationen_US
dc.subjectvirusesen_US
dc.subjectwithin-host evolutionen_US
dc.titleWithin-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infectionen_US
dc.typeJournal Articleen_US
dc.source.journaltitleJournal of virology
dc.source.beginpagee0161823
dc.source.endpage
dc.source.countryUnited States
dc.identifier.journalJournal of virology
dc.contributor.departmentMedicineen_US
dc.contributor.departmentPediatricsen_US


This item appears in the following Collection(s)

Show simple item record