Vitamin B produced by gut bacteria modulates cholinergic signalling
AuthorsKang, Woo Kyu
Florman, Jeremy T
Fox, Bennett W
Schroeder, Frank C
Walhout, Albertha J M
Alkema, Mark J
Document TypeJournal Article
MetadataShow full item record
AbstractA growing body of evidence indicates that gut microbiota influence brain function and behaviour. However, the molecular basis of how gut bacteria modulate host nervous system function is largely unknown. Here we show that vitamin B12-producing bacteria that colonize the intestine can modulate excitatory cholinergic signalling and behaviour in the host Caenorhabditis elegans. Here we demonstrate that vitamin B12 reduces cholinergic signalling in the nervous system through rewiring of the methionine (Met)/S-adenosylmethionine cycle in the intestine. We identify a conserved metabolic crosstalk between the methionine/S-adenosylmethionine cycle and the choline-oxidation pathway. In addition, we show that metabolic rewiring of these pathways by vitamin B12 reduces cholinergic signalling by limiting the availability of free choline required by neurons to synthesize acetylcholine. Our study reveals a gut-brain communication pathway by which enteric bacteria modulate host behaviour and may affect neurological health.
SourceKang WK, Florman JT, Araya A, Fox BW, Thackeray A, Schroeder FC, Walhout AJM, Alkema MJ. Vitamin B12 produced by gut bacteria modulates cholinergic signalling. Nat Cell Biol. 2024 Jan 2. doi: 10.1038/s41556-023-01299-2. Epub ahead of print. PMID: 38168768.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/52966
Rights© 2024. The Author(s), under exclusive licence to Springer Nature Limited.