A neuronal coping mechanism linking stress-induced anxiety to motivation for reward
AuthorsKlenowski, Paul M
Freels, Timothy G
Tapper, Andrew R
Student AuthorsMax Zinter
UMass Chan AffiliationsBiochemistry and Molecular Biotechnology
Brudnick Neuropsychiatric Research Institute
Document TypeJournal Article
MetadataShow full item record
AbstractStress coping involves innate and active motivational behaviors that reduce anxiety under stressful situations. However, the neuronal bases directly linking stress, anxiety, and motivation are largely unknown. Here, we show that acute stressors activate mouse GABAergic neurons in the interpeduncular nucleus (IPN). Stress-coping behavior including self-grooming and reward behavior including sucrose consumption inherently reduced IPN GABAergic neuron activity. Optogenetic silencing of IPN GABAergic neuron activation during acute stress episodes mimicked coping strategies and alleviated anxiety-like behavior. In a mouse model of stress-enhanced motivation for sucrose seeking, photoinhibition of IPN GABAergic neurons reduced stress-induced motivation for sucrose, whereas photoactivation of IPN GABAergic neurons or excitatory inputs from medial habenula potentiated sucrose seeking. Single-cell sequencing, fiber photometry, and optogenetic experiments revealed that stress-activated IPN GABAergic neurons that drive motivated sucrose seeking express somatostatin. Together, these data suggest that stress induces innate behaviors and motivates reward seeking to oppose IPN neuronal activation as an anxiolytic stress-coping mechanism.
SourceKlenowski PM, Zhao-Shea R, Freels TG, Molas S, Zinter M, M'Angale P, Xiao C, Martinez-Núñez L, Thomson T, Tapper AR. A neuronal coping mechanism linking stress-induced anxiety to motivation for reward. Sci Adv. 2023 Dec 8;9(49):eadh9620. doi: 10.1126/sciadv.adh9620. Epub 2023 Dec 6. PMID: 38055830; PMCID: PMC10699782.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/52992
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Except where otherwise noted, this item's license is described as Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).