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dc.contributor.authorLevine, Zoë C
dc.contributor.authorSene, Aita
dc.contributor.authorMkandawire, Winnie
dc.contributor.authorDeme, Awa B
dc.contributor.authorNdiaye, Tolla
dc.contributor.authorSy, Mouhamad
dc.contributor.authorGaye, Amy
dc.contributor.authorDiedhiou, Younouss
dc.contributor.authorMbaye, Amadou M
dc.contributor.authorNdiaye, Ibrahima M
dc.contributor.authorGomis, Jules
dc.contributor.authorNdiop, Médoune
dc.contributor.authorSene, Doudou
dc.contributor.authorFaye Paye, Marietou
dc.contributor.authorMacInnis, Bronwyn L
dc.contributor.authorSchaffner, Stephen F
dc.contributor.authorPark, Daniel J
dc.contributor.authorBadiane, Aida S
dc.contributor.authorColubri, Andrés
dc.contributor.authorNdiaye, Mouhamadou
dc.contributor.authorSy, Ngayo
dc.contributor.authorSabeti, Pardis C
dc.contributor.authorNdiaye, Daouda
dc.contributor.authorSiddle, Katherine J
dc.date.accessioned2024-02-27T19:55:15Z
dc.date.available2024-02-27T19:55:15Z
dc.date.issued2024-01-25
dc.identifier.citationLevine ZC, Sene A, Mkandawire W, Deme AB, Ndiaye T, Sy M, Gaye A, Diedhiou Y, Mbaye AM, Ndiaye IM, Gomis J, Ndiop M, Sene D, Faye Paye M, MacInnis BL, Schaffner SF, Park DJ, Badiane AS, Colubri A, Ndiaye M, Sy N, Sabeti PC, Ndiaye D, Siddle KJ. Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing. Nat Commun. 2024 Jan 25;15(1):747. doi: 10.1038/s41467-024-44800-7. PMID: 38272885; PMCID: PMC10810818.en_US
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-024-44800-7en_US
dc.identifier.pmid38272885
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53099
dc.description.abstractThe worldwide decline in malaria incidence is revealing the extensive burden of non-malarial febrile illness (NMFI), which remains poorly understood and difficult to diagnose. To characterize NMFI in Senegal, we collected venous blood and clinical metadata in a cross-sectional study of febrile patients and healthy controls in a low malaria burden area. Using 16S and untargeted sequencing, we detected viral, bacterial, or eukaryotic pathogens in 23% (38/163) of NMFI cases. Bacteria were the most common, with relapsing fever Borrelia and spotted fever Rickettsia found in 15.5% and 3.8% of cases, respectively. Four viral pathogens were found in a total of 7 febrile cases (3.5%). Sequencing also detected undiagnosed Plasmodium, including one putative P. ovale infection. We developed a logistic regression model that can distinguish Borrelia from NMFIs with similar presentation based on symptoms and vital signs (F1 score: 0.823). These results highlight the challenge and importance of improved diagnostics, especially for Borrelia, to support diagnosis and surveillance.en_US
dc.language.isoenen_US
dc.relation.ispartofNature Communicationsen_US
dc.relation.urlhttps://doi.org/10.1038/s41467-024-44800-7en_US
dc.rightsOpen Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2024en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGenomicsen_US
dc.subjectInfectious diseasesen_US
dc.subjectMicrobial geneticsen_US
dc.titleInvestigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencingen_US
dc.typeJournal Articleen_US
dc.source.journaltitleNature communications
dc.source.volume15
dc.source.issue1
dc.source.beginpage747
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.identifier.journalNature communications
refterms.dateFOA2024-02-27T19:55:17Z
dc.contributor.departmentGenomics and Computational Biologyen_US
dc.contributor.departmentMorningside Graduate School of Biomedical Sciencesen_US
dc.contributor.studentWinnie Mkandawire


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Open Access: This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as
long as you give appropriate credit to the original author(s) and the
source, provide a link to the Creative Commons licence, and indicate if
changes were made. The images or other third party material in this
article are included in the article’s Creative Commons licence, unless
indicated otherwise in a credit line to the material. If material is not
included in the article’s Creative Commons licence and your intended
use is not permitted by statutory regulation or exceeds the permitted
use, you will need to obtain permission directly from the copyright
holder. To view a copy of this licence, visit http://creativecommons.org/
licenses/by/4.0/.
© The Author(s) 2024
Except where otherwise noted, this item's license is described as Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2024