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dc.contributor.authorWang, Bo
dc.contributor.authorJanamnuaysook, Rena
dc.contributor.authorMacDonell, Karen
dc.contributor.authorRongkavilit, Chokechai
dc.contributor.authorSchieber, Elizabeth
dc.contributor.authorNaar, Sylvie
dc.contributor.authorPhanuphak, Nittaya
dc.date.accessioned2024-03-04T20:36:29Z
dc.date.available2024-03-04T20:36:29Z
dc.date.issued2023-09-04
dc.identifier.citationWang B, Janamnuaysook R, MacDonell K, Rongkavilit C, Schieber E, Naar S, Phanuphak N. Adapting Effective mHealth Interventions to Improve Uptake and Adherence to HIV Pre-Exposure Prophylaxis Among Thai Young Men Who Have Sex With Men: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2023 Sep 4;12:e46435. doi: 10.2196/46435. PMID: 37665622; PMCID: PMC10507518.en_US
dc.identifier.issn1929-0748
dc.identifier.doi10.2196/46435en_US
dc.identifier.pmid37665622
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53137
dc.description.abstractBackground: Young men who have sex with men (YMSM) are the fastest-growing HIV-positive population worldwide. Thailand has the highest adult HIV seroprevalence in Asia; over 25% of men having sex with men in Bangkok are HIV positive. Pre-exposure prophylaxis (PrEP) is an efficacious HIV prevention strategy recommended for all at-risk individuals. PrEP is highly effective when taken as prescribed, but PrEP utilization rate has been low, and adherence is often inadequate. Objective: We propose to develop and pilot a multicomponent, technology-based intervention to promote motivation to begin PrEP ("uptake") and sustained adherence to PrEP among HIV-negative Thai YMSM. We will adapt an existing 2-session technology-delivered, motivational interviewing-based intervention to focus on PrEP use in YMSM in Thailand. The resulting intervention is called the Motivational Enhancement System for PrEP Uptake and Adherence (MES-PrEP). We will also develop motivational text messaging (MTM) to send two-way motivational messages to promote PrEP use. Methods: The proposed study includes 3 phases. Phase 1 includes in-depth interviews with HIV-negative Thai YMSM and providers to explore barriers and facilitators of PrEP initiation and adherence, aiming to inform intervention content. Phase 2 consists of adapting and beta-testing MES-PrEP and MTM for functionality and feasibility using a youth advisory board of Thai YMSM. In Phase 3, we will conduct a pilot randomized controlled trial to evaluate the feasibility, acceptability, and preliminary efficacy of MES-PrEP and MTM to increase PrEP uptake and adherence among Thai YMSM. A total of 60 HIV-negative Thai YMSM who have not started PrEP and 60 YMSM who are on PrEP but not adherent to it will be randomized 2:1 to receive MES-PrEP and MTM (n=40) or standard PrEP counseling (n=20). The feasibility and acceptability of the intervention will be assessed through usage patterns and the System Usability Scale. The preliminary impact will be assessed by evaluating the proportion of PrEP initiation and level of adherence to PrEP. Participants will complete the assessments at baseline and at 1-, 3-, and 6-month postintervention. Biomarkers of adherence to PrEP and biomarkers of HIV and sexually transmitted infections will be collected. Results: Recruitment for this study began in January 2022 for phase 1. Qualitative interviews were completed with 30 YMSM and 5 clinical providers in May 2022. Phase 3, the pilot feasibility and acceptability trial, began in July 2023. Upon project completion, we shall have developed a highly innovative mobile health intervention to support YMSM using PrEP, which will be ready for testing in a larger efficacy trial. Conclusions: This study addresses a critical problem (ie, high HIV incidence and low PrEP use) among Thai YMSM. We are developing 2 potentially synergistic technology-based, theory-driven interventions aimed at maximizing PrEP use. The proposed project has the potential to make significant contributions to advancing HIV prevention research and implementation science. Trial registration: ClinicalTrials.gov NCT05243030; https://clinicaltrials.gov/ct2/show/NCT05243030. International registered report identifier (irrid): DERR1-10.2196/46435.en_US
dc.language.isoenen_US
dc.relation.ispartofJMIR Research Protocolsen_US
dc.relation.urlhttps://doi.org/10.2196/46435en_US
dc.rights©Bo Wang, Rena Janamnuaysook, Karen MacDonell, Chokechai Rongkavilit, Elizabeth Schieber, Sylvie Naar, Nittaya Phanuphak. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 04.09.2023. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on https://www.researchprotocols.org, as well as this copyright and license information must be included.en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHIV preventionen_US
dc.subjectPrEPen_US
dc.subjectThailanden_US
dc.subjectmHealthen_US
dc.subjectmotivational interviewingen_US
dc.subjectmotivational text messagingen_US
dc.subjectpre-exposure prophylaxisen_US
dc.subjectyoung men who have sex with menen_US
dc.titleAdapting Effective mHealth Interventions to Improve Uptake and Adherence to HIV Pre-Exposure Prophylaxis Among Thai Young Men Who Have Sex With Men: Protocol for a Randomized Controlled Trialen_US
dc.typeJournal Articleen_US
dc.source.journaltitleJMIR research protocols
dc.source.volume12
dc.source.beginpagee46435
dc.source.endpage
dc.source.countryUnited States
dc.source.countryCanada
dc.identifier.journalJMIR research protocols
refterms.dateFOA2024-03-04T20:36:31Z
dc.contributor.departmentBiostatistics and Health Services Researchen_US
dc.contributor.departmentPopulation and Quantitative Health Sciencesen_US


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©Bo Wang, Rena Janamnuaysook, Karen MacDonell, Chokechai Rongkavilit, Elizabeth Schieber, Sylvie Naar, Nittaya Phanuphak.
Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 04.09.2023. This is an open-access article
distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR
Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on
https://www.researchprotocols.org, as well as this copyright and license information must be included.
Except where otherwise noted, this item's license is described as ©Bo Wang, Rena Janamnuaysook, Karen MacDonell, Chokechai Rongkavilit, Elizabeth Schieber, Sylvie Naar, Nittaya Phanuphak. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 04.09.2023. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on https://www.researchprotocols.org, as well as this copyright and license information must be included.