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dc.contributor.authorJiang, Yuying
dc.contributor.authorYang, Yongbing
dc.contributor.authorHu, Yingchao
dc.contributor.authorYang, Rui
dc.contributor.authorHuang, Jiajia
dc.contributor.authorLiu, Yi
dc.contributor.authorWu, Yuqing
dc.contributor.authorLi, Sheng
dc.contributor.authorMa, Chunmei
dc.contributor.authorHumphries, Fiachra
dc.contributor.authorWang, Bingwei
dc.contributor.authorWang, Xi
dc.contributor.authorHu, Zhibin
dc.contributor.authorYang, Shuo
dc.date.accessioned2024-03-08T21:41:36Z
dc.date.available2024-03-08T21:41:36Z
dc.date.issued2022-10-25
dc.identifier.citationJiang Y, Yang Y, Hu Y, Yang R, Huang J, Liu Y, Wu Y, Li S, Ma C, Humphries F, Wang B, Wang X, Hu Z, Yang S. Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade. Cell Rep. 2022 Oct 25;41(4):111553. doi: 10.1016/j.celrep.2022.111553. PMID: 36288704.en_US
dc.identifier.eissn2211-1247
dc.identifier.doi10.1016/j.celrep.2022.111553en_US
dc.identifier.pmid36288704
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53144
dc.description.abstractTumor microenvironments (TMEs) require co-operation of innate and adaptive immune cells, which influence tumor progression and immunotherapy. Caspase-activated gasdermins facilitate tumor death and promote anti-tumor immunity. How pyroptosis in immune cells affects the TME remains unclear. TME expression of gasdermin D (GSDMD) is highly expressed in antigen-presenting cells (APCs) and correlates with immune checkpoint signatures. Through conditional deletion of GSDMD, we demonstrate that GSDMD in TME APCs restricts anti-tumor immunity during PD-L1 inhibition. Loss of GSDMD in APCs enhances interferon-stimulated genes (ISGs), thereby promoting CD8+ T cell activation in a cGAS-dependent manner. Moreover, pharmacological inhibition of GSDMD-mediated pyroptosis and PD-L1 improve anti-tumor immunity, highlighting the potential of combining GSDMD/PD-L1 inhibition for immunotherapy as a therapeutic strategy.en_US
dc.language.isoenen_US
dc.relation.ispartofCell Reportsen_US
dc.relation.urlhttps://doi.org/10.1016/j.celrep.2022.111553en_US
dc.rightsCopyright 2022 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCP: Canceren_US
dc.subjectCP: Immunologyen_US
dc.subjectGSDMDen_US
dc.subjectanti-tumor immunityen_US
dc.subjectmacrophage/DCen_US
dc.titleGasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockadeen_US
dc.typeJournal Articleen_US
dc.source.journaltitleCell reports
dc.source.volume41
dc.source.issue4
dc.source.beginpage111553
dc.source.endpage
dc.source.countryUnited States
dc.identifier.journalCell reports
refterms.dateFOA2024-03-08T21:41:38Z
dc.contributor.departmentMedicineen_US


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Copyright 2022 The Authors.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as Copyright 2022 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).