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dc.contributor.authorDmytriw, Adam A
dc.contributor.authorMusmar, Basel
dc.contributor.authorSalim, Hamza
dc.contributor.authorGhozy, Sherief
dc.contributor.authorSiegler, James E
dc.contributor.authorKobeissi, Hassan
dc.contributor.authorShaikh, Hamza
dc.contributor.authorKhalife, Jane
dc.contributor.authorAbdalkader, Mohamad
dc.contributor.authorKlein, Piers
dc.contributor.authorNguyen, Thanh N
dc.contributor.authorHeit, Jeremy J
dc.contributor.authorRegenhardt, Robert W
dc.contributor.authorCancelliere, Nicole M
dc.contributor.authorBernstock, Joshua D
dc.contributor.authorNaamani, Kareem El
dc.contributor.authorAmllay, Abdelaziz
dc.contributor.authorMeyer, Lukas
dc.contributor.authorDusart, Anne
dc.contributor.authorBellante, Flavio
dc.contributor.authorForestier, Géraud
dc.contributor.authorRouchaud, Aymeric
dc.contributor.authorSaleme, Suzana
dc.contributor.authorMounayer, Charbel
dc.contributor.authorFiehler, Jens
dc.contributor.authorKühn, Anna Luisa
dc.contributor.authorPuri, Ajit S
dc.contributor.authorDyzmann, Christian
dc.contributor.authorKan, Peter T
dc.contributor.authorColasurdo, Marco
dc.contributor.authorMarnat, Gaultier
dc.contributor.authorBerge, Jérôme
dc.contributor.authorBarreau, Xavier
dc.contributor.authorSibon, Igor
dc.contributor.authorNedelcu, Simona
dc.contributor.authorHenninger, Nils
dc.contributor.authorMarotta, Thomas R
dc.contributor.authorStapleton, Christopher J
dc.contributor.authorRabinov, James D
dc.contributor.authorOta, Takahiro
dc.contributor.authorDofuku, Shogo
dc.contributor.authorYeo, Leonard Ll
dc.contributor.authorTan, Benjamin Yq
dc.contributor.authorGopinathan, Anil
dc.contributor.authorMartinez-Gutierrez, Juan Carlos
dc.contributor.authorSalazar-Marioni, Sergio
dc.contributor.authorSheth, Sunil
dc.contributor.authorRenieri, Leonardo
dc.contributor.authorCapirossi, Carolina
dc.contributor.authorMowla, Ashkan
dc.contributor.authorChervak, Lina
dc.contributor.authorVagal, Achala
dc.contributor.authorAdeeb, Nimer
dc.contributor.authorCuellar-Saenz, Hugo H
dc.contributor.authorTjoumakaris, Stavropoula I
dc.contributor.authorJabbour, Pascal
dc.contributor.authorKhandelwal, Priyank
dc.contributor.authorBiswas, Arundhati
dc.contributor.authorClarençon, Frédéric
dc.contributor.authorElhorany, Mahmoud
dc.contributor.authorPremat, Kevin
dc.contributor.authorValente, Iacopo
dc.contributor.authorPedicelli, Alessandro
dc.contributor.authorFilipe, João Pedro
dc.contributor.authorVarela, Ricardo
dc.contributor.authorQuintero-Consuegra, Miguel
dc.contributor.authorGonzalez, Nestor R
dc.contributor.authorMöhlenbruch, Markus A
dc.contributor.authorJesser, Jessica
dc.contributor.authorCostalat, Vincent
dc.contributor.authorTer Schiphorst, Adrien
dc.contributor.authorYedavalli, Vivek
dc.contributor.authorHarker, Pablo
dc.contributor.authorAziz, Yasmin
dc.contributor.authorGory, Benjamin
dc.contributor.authorStracke, Christian Paul
dc.contributor.authorHecker, Constantin
dc.contributor.authorKadirvel, Ramanathan
dc.contributor.authorKiller-Oberpfalzer, Monika
dc.contributor.authorGriessenauer, Christoph J
dc.contributor.authorThomas, Ajith J
dc.contributor.authorHsieh, Cheng-Yang
dc.contributor.authorLiebeskind, David S
dc.contributor.authorAlexandru Radu, Răzvan
dc.contributor.authorAlexandre, Andrea M
dc.contributor.authorTancredi, Illario
dc.contributor.authorFaizy, Tobias D
dc.contributor.authorFahed, Robert
dc.contributor.authorWeyland, Charlotte
dc.contributor.authorLubicz, Boris
dc.contributor.authorPatel, Aman B
dc.contributor.authorPereira, Vitor Mendes
dc.contributor.authorGuenego, Adrien
dc.date.accessioned2024-03-21T13:42:26Z
dc.date.available2024-03-21T13:42:26Z
dc.date.issued2024-02-26
dc.identifier.citationDmytriw AA, Musmar B, Salim H, Ghozy S, Siegler JE, Kobeissi H, Shaikh H, Khalife J, Abdalkader M, Klein P, Nguyen TN, Heit JJ, Regenhardt RW, Cancelliere NM, Bernstock JD, Naamani KE, Amllay A, Meyer L, Dusart A, Bellante F, Forestier G, Rouchaud A, Saleme S, Mounayer C, Fiehler J, Kühn AL, Puri AS, Dyzmann C, Kan PT, Colasurdo M, Marnat G, Berge J, Barreau X, Sibon I, Nedelcu S, Henninger N, Marotta TR, Stapleton CJ, Rabinov JD, Ota T, Dofuku S, Yeo LL, Tan BY, Gopinathan A, Martinez-Gutierrez JC, Salazar-Marioni S, Sheth S, Renieri L, Capirossi C, Mowla A, Chervak L, Vagal A, Adeeb N, Cuellar-Saenz HH, Tjoumakaris SI, Jabbour P, Khandelwal P, Biswas A, Clarençon F, Elhorany M, Premat K, Valente I, Pedicelli A, Filipe JP, Varela R, Quintero-Consuegra M, Gonzalez NR, Möhlenbruch MA, Jesser J, Costalat V, Ter Schiphorst A, Yedavalli V, Harker P, Aziz Y, Gory B, Stracke CP, Hecker C, Kadirvel R, Killer-Oberpfalzer M, Griessenauer CJ, Thomas AJ, Hsieh CY, Liebeskind DS, Alexandru Radu R, Alexandre AM, Tancredi I, Faizy TD, Fahed R, Weyland C, Lubicz B, Patel AB, Pereira VM, Guenego A; MAD-MT Consortium. Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study. Eur Stroke J. 2024 Feb 26:23969873231219412. doi: 10.1177/23969873231219412. Epub ahead of print. PMID: 38409796.en_US
dc.identifier.eissn2396-9881
dc.identifier.doi10.1177/23969873231219412en_US
dc.identifier.pmid38409796
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53202
dc.description.abstractBackground: Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium vessel occlusion (MeVO) remain less explored. This multicenter, retrospective study aims to investigate the incidence and clinical outcomes of vessel perforations (confirmed by extravasation during an angiographic series) during MT for AIS caused by MeVO. Methods: Data were collected from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. A total of 1373 AIS patients with MeVO underwent MT. Baseline characteristics, procedural details, and clinical outcomes were analyzed. Results: The incidence of vessel perforation was 4.8% (66/1373). Notably, our analysis indicates variations in perforation rates across different arterial segments: 8.9% in M3 segments, 4.3% in M2 segments, and 8.3% in A2 segments (p = 0.612). Patients with perforation had significantly worse outcomes, with lower rates of favorable angiographic outcomes (TICI 2c-3: 23% vs 58.9%, p < 0.001; TICI 2b-3: 56.5% vs 88.3%, p < 0.001). Functional outcomes were also worse in the perforation group (mRS 0-1 at 3 months: 22.7% vs 36.6%, p = 0.031; mRS 0-2 at 3 months: 28.8% vs 53.9%, p < 0.001). Mortality was higher in the perforation group (30.3% vs 16.8%, p = 0.008). Conclusion: This study reveals that while the occurrence of vessel perforation in MT for AIS due to MeVO is relatively rare, it is associated with poor functional outcomes and higher mortality. The findings highlight the need for increased caution and specialized training in performing MT for MeVO. Further prospective research is required for risk mitigation strategies.en_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Stroke Journalen_US
dc.relation.urlhttps://doi.org/10.1177/23969873231219412en_US
dc.subjectAISen_US
dc.subjectMTen_US
dc.subjectMeVoen_US
dc.subjectStrokeen_US
dc.subjectmechanical thrombectomyen_US
dc.subjectperforationen_US
dc.titleIncidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational studyen_US
dc.typeJournal Articleen_US
dc.source.journaltitleEuropean stroke journal
dc.source.beginpage23969873231219412
dc.source.endpage
dc.source.countryEngland
dc.identifier.journalEuropean stroke journal
dc.contributor.departmentNeurologyen_US
dc.contributor.departmentPsychiatryen_US
dc.contributor.departmentRadiologyen_US


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