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dc.contributor.authorMokin, Maxim
dc.contributor.authorPionessa, Donald
dc.contributor.authorKoenigsknecht, Carmon
dc.contributor.authorGutierrez, Liza
dc.contributor.authorSetlur Nagesh, Swetadri Vasan
dc.contributor.authorMeess Tuttle, Karen M
dc.contributor.authorSpengler, Mike
dc.contributor.authorAkkad, Yousef
dc.contributor.authorVakharia, Kunal
dc.contributor.authorShapiro, Maksim
dc.contributor.authorGounis, Matthew J
dc.contributor.authorLevy, Elad I
dc.contributor.authorSiddiqui, Adnan H
dc.date.accessioned2024-03-21T14:47:55Z
dc.date.available2024-03-21T14:47:55Z
dc.date.issued2024-02-22
dc.identifier.citationMokin M, Pionessa D Jr, Koenigsknecht C, Gutierrez L, Setlur Nagesh SV, Meess Tuttle KM, Spengler M, Akkad Y, Vakharia K, Shapiro M, Gounis MJ, Levy EI, Siddiqui AH. A novel swine model of selective middle meningeal artery catheterization and embolization. J Neurointerv Surg. 2024 Feb 22:jnis-2024-021481. doi: 10.1136/jnis-2024-021481. Epub ahead of print. PMID: 38388479.en_US
dc.identifier.eissn1759-8486
dc.identifier.doi10.1136/jnis-2024-021481en_US
dc.identifier.pmid38388479
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53207
dc.description.abstractBackground: Middle meningeal artery (MMA) embolization is a promising intervention as a stand-alone or adjunct treatment to surgery in patients with chronic subdural hematomas. There are currently no large animal models for selective access and embolization of the MMA for preclinical evaluation of this endovascular modality. Our objective was to introduce a novel in vivo model of selective MMA embolization in swine. Methods: Diagnostic cerebral angiography with selective microcatheter catheterization into the MMA was performed under general anesthesia in five swine. Anatomical variants in arterial meningeal supply were examined. In two animals, subsequent embolization of the MMA with a liquid embolic agent (Onyx-18) was performed, followed by brain tissue harvest and histological analysis. Results: The MMA was consistently localized as a branch of the internal maxillary artery just distal to the origin of the ascending pharyngeal artery. Additional meningeal supply was observed from the external ophthalmic artery, although not present consistently. MMA embolization with Onyx was technically successful and feasible. Histological analysis showed Onyx material within the MMA lumen. Conclusions: Microcatheter access into the MMA in swine with liquid embolic agent delivery represents a reproducible model of MMA embolization. Anatomical variations in the distribution of arterial supply to the meninges exist. This model has a potential application for comparing therapeutic effects of various embolic agents in a preclinical setting that closely resembles the MMA embolization procedure in humans.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of NeuroInterventional Surgeryen_US
dc.relation.urlhttps://doi.org/10.1136/jnis-2024-021481en_US
dc.rights© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.en_US
dc.subjectArteryen_US
dc.subjectCatheteren_US
dc.subjectLiquid Embolic Materialen_US
dc.subjectSubduralen_US
dc.subjectTechniqueen_US
dc.titleA novel swine model of selective middle meningeal artery catheterization and embolizationen_US
dc.typeJournal Articleen_US
dc.source.journaltitleJournal of neurointerventional surgery
dc.source.countryEngland
dc.identifier.journalJournal of neurointerventional surgery
dc.contributor.departmentRadiologyen_US


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