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dc.contributor.authorYoung, Taylor
dc.contributor.authorKumar, Vinod Jangid
dc.contributor.authorSaranathan, Manojkumar
dc.date.accessioned2024-04-11T14:34:45Z
dc.date.available2024-04-11T14:34:45Z
dc.date.issued2024-03-08
dc.identifier.citationYoung T, Kumar VJ, Saranathan M. Normative modeling of thalamic nuclear volumes. medRxiv [Preprint]. 2024 Mar 8:2024.03.06.24303871. doi: 10.1101/2024.03.06.24303871. PMID: 38496426; PMCID: PMC10942522.en_US
dc.identifier.doi10.1101/2024.03.06.24303871en_US
dc.identifier.pmid38496426
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53282
dc.descriptionThis article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.en_US
dc.description.abstractThalamic nuclei have been implicated in neurodegenerative and neuropsychiatric disorders. Normative models for thalamic nuclear volumes have not been proposed thus far. The aim of this work was to establish normative models of thalamic nuclear volumes and subsequently investigate changes in thalamic nuclei in cognitive and psychiatric disorders. Volumes of the bilateral thalami and 12 nuclear regions were generated from T1 MRI data using a novel segmentation method (HIPS-THOMAS) in healthy control subjects (n=2374) and non-control subjects (n=695) with early and late mild cognitive impairment (EMCI, LMCI), Alzheimer's disease (AD), Early psychosis and Schizophrenia, Bipolar disorder, and Attention deficit hyperactivity disorder. Three different normative modelling methods were evaluated while controlling for sex, intracranial volume, and site. Z-scores and extreme z-score deviations were calculated and compared across phenotypes. GAMLSS models performed the best. Statistically significant shifts in z-score distributions consistent with atrophy were observed for most phenotypes. Shifts of progressively increasing magnitude were observed bilaterally from EMCI to AD with larger shifts in the left thalamic regions. Heterogeneous shifts were observed in psychiatric diagnoses with a predilection for the right thalamic regions. Here we present the first normative models of thalamic nuclear volumes and highlight their utility in evaluating heterogenous disorders such as Schizophrenia.en_US
dc.language.isoenen_US
dc.relation.ispartofmedRxiven_US
dc.relation.urlhttps://doi.org/10.1101/2024.03.06.24303871en_US
dc.rightsThe copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPsychiatry and Clinical Psychologyen_US
dc.subjectthalamic nucleien_US
dc.subjectcognitive and psychiatric disordersen_US
dc.titleNormative modeling of thalamic nuclear volumes [preprint]en_US
dc.typePreprinten_US
dc.source.journaltitlemedRxiv : the preprint server for health sciences
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalmedRxiv : the preprint server for health sciences
refterms.dateFOA2024-04-11T14:34:46Z
dc.contributor.departmentNeurologyen_US
dc.contributor.departmentPsychiatryen_US
dc.contributor.departmentRadiologyen_US


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The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Except where otherwise noted, this item's license is described as The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.