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dc.contributor.authorRíos, Ana Sofía
dc.contributor.authorOxenford, Simón
dc.contributor.authorNeudorfer, Clemens
dc.contributor.authorButenko, Konstantin
dc.contributor.authorLi, Ningfei
dc.contributor.authorRajamani, Nanditha
dc.contributor.authorBoutet, Alexandre
dc.contributor.authorElias, Gavin J B
dc.contributor.authorGermann, Jurgen
dc.contributor.authorLoh, Aaron
dc.contributor.authorDeeb, Wissam
dc.contributor.authorWang, Fuyixue
dc.contributor.authorSetsompop, Kawin
dc.contributor.authorSalvato, Bryan
dc.contributor.authorAlmeida, Leonardo Brito de
dc.contributor.authorFoote, Kelly D
dc.contributor.authorAmaral, Robert
dc.contributor.authorRosenberg, Paul B
dc.contributor.authorTang-Wai, David F
dc.contributor.authorWolk, David A
dc.contributor.authorBurke, Anna D
dc.contributor.authorSalloway, Stephen
dc.contributor.authorSabbagh, Marwan N
dc.contributor.authorChakravarty, M Mallar
dc.contributor.authorSmith, Gwenn S
dc.contributor.authorLyketsos, Constantine G
dc.contributor.authorOkun, Michael S
dc.contributor.authorAnderson, William S
dc.contributor.authorMari, Zoltan
dc.contributor.authorPonce, Francisco A
dc.contributor.authorLozano, Andres M
dc.contributor.authorHorn, Andreas
dc.date.accessioned2024-04-26T20:02:50Z
dc.date.available2024-04-26T20:02:50Z
dc.date.issued2022-12-14
dc.identifier.citationRíos AS, Oxenford S, Neudorfer C, Butenko K, Li N, Rajamani N, Boutet A, Elias GJB, Germann J, Loh A, Deeb W, Wang F, Setsompop K, Salvato B, Almeida LB, Foote KD, Amaral R, Rosenberg PB, Tang-Wai DF, Wolk DA, Burke AD, Salloway S, Sabbagh MN, Chakravarty MM, Smith GS, Lyketsos CG, Okun MS, Anderson WS, Mari Z, Ponce FA, Lozano AM, Horn A. Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease. Nat Commun. 2022 Dec 14;13(1):7707. doi: 10.1038/s41467-022-34510-3. PMID: 36517479; PMCID: PMC9751139.en_US
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-022-34510-3en_US
dc.identifier.pmid36517479
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53312
dc.description.abstractDeep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures (R = 0.48, p < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes (R = 0.48, p < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming.en_US
dc.language.isoenen_US
dc.relation.ispartofNature Communicationsen_US
dc.relation.urlhttps://doi.org/10.1038/s41467-022-34510-3en_US
dc.rightsOpen Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2022en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAlzheimer's diseaseen_US
dc.subjectTranslational researchen_US
dc.titleOptimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's diseaseen_US
dc.typeJournal Articleen_US
dc.source.journaltitleNature communications
dc.source.volume13
dc.source.issue1
dc.source.beginpage7707
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.identifier.journalNature communications
refterms.dateFOA2024-04-26T20:02:52Z
dc.contributor.departmentNeurologyen_US


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Open Access: This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as
long as you give appropriate credit to the original author(s) and the
source, provide a link to the Creative Commons license, and indicate if
changes were made. The images or other third party material in this
article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not
included in the article’s Creative Commons license and your intended
use is not permitted by statutory regulation or exceeds the permitted
use, you will need to obtain permission directly from the copyright
holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.
© The Author(s) 2022
Except where otherwise noted, this item's license is described as Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2022