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dc.contributor.authorAndreeva, T V
dc.contributor.authorGusev, F E
dc.contributor.authorSinyakova, N A
dc.contributor.authorKulikov, A V
dc.contributor.authorGrigorenko, A P
dc.contributor.authorAdrianova, I Yu
dc.contributor.authorBazovkina, D V
dc.contributor.authorRogaev, Evgeny I
dc.date.accessioned2024-06-03T14:48:42Z
dc.date.available2024-06-03T14:48:42Z
dc.date.issued2023-01-01
dc.identifier.citationAndreeva TV, Gusev FE, Sinyakova NA, Kulikov AV, Grigorenko AP, Adrianova IY, Bazovkina DV, Rogaev EI. An Analysis of Genetic Predisposition to Hereditary Catalepsy in a Mouse Model of Neuropsychiatric Disorders Using Whole-Genome Sequencing Data. Acta Naturae. 2023 Jan-Mar;15(1):26-30. doi: 10.32607/actanaturae.11875. PMID: 37153504; PMCID: PMC10154780.en_US
dc.identifier.issn2075-8251
dc.identifier.doi10.32607/actanaturae.11875en_US
dc.identifier.pmid37153504
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53399
dc.description.abstractCatalepsy is a behavioral condition that is associated with severe psychopathologies, including schizophrenia, depression, and Parkinson's disease. In some mouse strains, catalepsy can be induced by pinching the skin at the scruff of the neck. The main locus of hereditary catalepsy in mice has recently been linked to the 105-115 Mb fragment of mouse chromosome 13 by QTL analysis. We performed whole-genome sequencing of catalepsy-resistant and catalepsy-prone mouse strains in order to pinpoint the putative candidate genes related to hereditary catalepsy in mice. We remapped the previously described main locus for hereditary catalepsy in mice to the chromosome region 103.92-106.16 Mb. A homologous human region on chromosome 5 includes genetic and epigenetic variants associated with schizophrenia. Furthermore, we identified a missense variant in catalepsy-prone strains within the Nln gene. Nln encodes neurolysin, which degrades neurotensin, a peptide reported to induce catalepsy in mice. Our data suggest that Nln is the most probable candidate for the role of major gene of hereditary, pinch-induced catalepsy in mice and point to a shared molecular pathway between catalepsy in mice and human neuropsychiatric disorders.en_US
dc.language.isoenen_US
dc.relation.ispartofActa Naturaeen_US
dc.relation.urlhttps://doi.org/10.32607/actanaturae.11875en_US
dc.rightsCopyright © 2023 National Research University Higher School of Economics. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectbrainen_US
dc.subjectcatalepsyen_US
dc.subjectgenomeen_US
dc.subjectmiceen_US
dc.subjectneurolysinen_US
dc.titleAn Analysis of Genetic Predisposition to Hereditary Catalepsy in a Mouse Model of Neuropsychiatric Disorders Using Whole-Genome Sequencing Dataen_US
dc.typeJournal Articleen_US
dc.source.journaltitleActa naturae
dc.source.volume15
dc.source.issue1
dc.source.beginpage26
dc.source.endpage30
dc.source.countryRussia (Federation)
dc.identifier.journalActa naturae
refterms.dateFOA2024-06-03T14:48:44Z
dc.contributor.departmentPsychiatryen_US


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Copyright © 2023 National Research University Higher School of Economics. This is an open access article distributed under the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright © 2023 National Research University Higher School of Economics. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.