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Regulation of innate immune signaling by IRAK proteins

dc.contributor.authorPereira, Milton
dc.contributor.authorGazzinelli, Ricardo T
dc.date.accessioned2024-06-10T14:56:05Z
dc.date.available2024-06-10T14:56:05Z
dc.date.issued2023-02-14
dc.identifier.citationPereira M, Gazzinelli RT. Regulation of innate immune signaling by IRAK proteins. Front Immunol. 2023 Feb 14;14:1133354. doi: 10.3389/fimmu.2023.1133354. PMID: 36865541; PMCID: PMC9972678.en_US
dc.identifier.eissn1664-3224
dc.identifier.doi10.3389/fimmu.2023.1133354en_US
dc.identifier.pmid36865541
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53451
dc.description.abstractThe Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1R) families are of paramount importance in coordinating the early immune response to pathogens. Signaling via most TLRs and IL-1Rs is mediated by the protein myeloid differentiation primary-response protein 88 (MyD88). This signaling adaptor forms the scaffold of the myddosome, a molecular platform that employs IL-1R-associated kinase (IRAK) proteins as main players for transducing signals. These kinases are essential in controlling gene transcription by regulating myddosome assembly, stability, activity and disassembly. Additionally, IRAKs play key roles in other biologically relevant responses such as inflammasome formation and immunometabolism. Here, we summarize some of the key aspects of IRAK biology in innate immunity.en_US
dc.language.isoenen_US
dc.relation.ispartofFrontiers in Immunologyen_US
dc.relation.urlhttps://doi.org/10.3389/fimmu.2023.1133354en_US
dc.rights© 2023 Pereira and Gazzinelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectIL-1Ren_US
dc.subjectIRAKen_US
dc.subjectTLRen_US
dc.subjectcell signalingen_US
dc.subjectinflammationen_US
dc.subjectinnate immunityen_US
dc.titleRegulation of innate immune signaling by IRAK proteinsen_US
dc.typeJournal Articleen_US
dc.source.journaltitleFrontiers in immunology
dc.source.volume14
dc.source.beginpage1133354
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countrySwitzerland
dc.identifier.journalFrontiers in immunology
refterms.dateFOA2024-06-10T14:56:07Z
dc.contributor.departmentMedicineen_US


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© 2023 Pereira and Gazzinelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as © 2023 Pereira and Gazzinelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.