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dc.contributor.authorPells, Sophia
dc.contributor.authorZeraatkar, Navid
dc.contributor.authorKalluri, Kesava S
dc.contributor.authorMoore, Stephen C
dc.contributor.authorMay, Micaehla
dc.contributor.authorFurenlid, Lars R
dc.contributor.authorKupinski, Matthew A
dc.contributor.authorKuo, Phillip H
dc.contributor.authorKing, Michael A
dc.date.accessioned2024-06-14T18:24:43Z
dc.date.available2024-06-14T18:24:43Z
dc.date.issued2024-06-06
dc.identifier.citationPells S, Zeraatkar N, Kalluri KS, Moore SC, May M, Furenlid LR, Kupinski MA, Kuo PH, King MA. Correction of multiplexing artefacts in multi-pinhole SPECT through temporal shuttering, de-multiplexing of projections, and alternating reconstruction. Phys Med Biol. 2024 Jun 6;69(12). doi: 10.1088/1361-6560/ad4f47. PMID: 38776948.en_US
dc.identifier.eissn1361-6560
dc.identifier.doi10.1088/1361-6560/ad4f47en_US
dc.identifier.pmid38776948
dc.identifier.urihttp://hdl.handle.net/20.500.14038/53491
dc.description.abstractObjective.Single-photon emission computed tomography (SPECT) with pinhole collimators can provide high-resolution imaging, but is often limited by low sensitivity. Acquiring projections simultaneously through multiple pinholes affords both high resolution and high sensitivity. However, the overlap of projections from different pinholes on detectors, known as multiplexing, has been shown to cause artefacts which degrade reconstructed images.Approach.Multiplexed projection sets were considered here using an analytic simulation model of AdaptiSPECT-C-a brain-dedicated multi-pinhole SPECT system. AdaptiSPECT-C has fully adaptable aperture shutters, so can acquire projections with a combination of multiplexed and non-multiplexed frames using temporal shuttering. Two strategies for reducing multiplex artefacts were considered: an algorithm to de-multiplex projections, and an alternating reconstruction strategy for projections acquired with a combination of multiplexed and non-multiplexed frames. Geometric and anthropomorphic digital phantoms were used to assess a number of metrics.Main results.Both de-multiplexing strategies showed a significant reduction in image artefacts and improved fidelity, image uniformity, contrast recovery and activity recovery (AR). In all cases, the two de-multiplexing strategies resulted in superior metrics to those from images acquired with only mux-free frames. The de-multiplexing algorithm provided reduced image noise and superior uniformity, whereas the alternating strategy improved contrast and AR.Significance.The use of these de-multiplexing algorithms means that multi-pinhole SPECT systems can acquire projections with more multiplexing without degradation of images.en_US
dc.language.isoenen_US
dc.relation.ispartofPhysics in Medicine & Biologyen_US
dc.relation.urlhttps://doi.org/10.1088/1361-6560/ad4f47en_US
dc.rights© 2024 Institute of Physics and Engineering in Medicine.en_US
dc.subjectbrain SPECTen_US
dc.subjectde-multiplexen_US
dc.subjectmulti-pinholeen_US
dc.subjectmultipinhole SPECTen_US
dc.subjectmultiplexen_US
dc.subjecttemporal shutteringen_US
dc.titleCorrection of multiplexing artefacts in multi-pinhole SPECT through temporal shuttering, de-multiplexing of projections, and alternating reconstructionen_US
dc.typeJournal Articleen_US
dc.source.journaltitlePhysics in medicine and biology
dc.source.volume69
dc.source.issue12
dc.source.countryEngland
dc.identifier.journalPhysics in medicine and biology
dc.contributor.departmentRadiologyen_US


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