Distinct members of the Caenorhabditis elegans CeMbio reference microbiota exert cryptic virulence that is masked by host defense
Student Authors
Xavier GonzalezAcademic Program
Immunology and MicrobiologyUMass Chan Affiliations
Microbiology and Physiological SystemsMorningside Graduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2024-04-16Keywords
C. elegansMAPK
TFEB
Wnt
cryptic virulence
gene expression
host defense
innate immunity
intestine
microbiota
Metadata
Show full item recordAbstract
Microbiotas are complex microbial communities that colonize specific niches in the host and provide essential organismal functions that are important in health and disease. Understanding the ability of each distinct community member to promote or impair host health, alone or in the context of the community, is imperative for understanding how differences in community structure affect host health and vice versa. Recently, a reference 12-member microbiota for the model organism Caenorhabditis elegans, known as CeMbio, was defined. Here, we show the differential ability of each CeMbio bacterial species to activate innate immunity through the conserved PMK-1/p38 MAPK, ACh-WNT, and HLH-30/TFEB pathways. Although distinct CeMbio members differed in their ability to activate the PMK-1/p38 pathway, the ability to do so did not correlate with bacterial-induced lifespan reduction in wild-type or immunodeficient animals. In contrast, most species activated HLH-30/TFEB and showed virulence toward hlh-30-deficient animals. These results suggest that the microbiota of C. elegans is rife with bacteria that can shorten the host's lifespan if host defense is compromised and that HLH-30/TFEB is a fundamental and key host protective factor.Source
Gonzalez X, Irazoqui JE. Distinct members of the Caenorhabditis elegans CeMbio reference microbiota exert cryptic virulence that is masked by host defense. Mol Microbiol. 2024 Apr 16. doi: 10.1111/mmi.15258. Epub ahead of print. PMID: 38623070.DOI
10.1111/mmi.15258Permanent Link to this Item
http://hdl.handle.net/20.500.14038/53536PubMed ID
38623070Related Resources
This article is based on a previously available preprint in bioRxiv, https://doi.org/10.1101/2023.11.02.565327.Rights
© 2024 John Wiley & Sons Ltd.ae974a485f413a2113503eed53cd6c53
10.1111/mmi.15258