Oxygen Sensor-Guided Fine Needle Biopsy Studies of Human Cancer Xenografts in Mice [preprint]
Abstract
An oxygen sensor-mounted fine-needle biopsy tool was used for in vivo measurement of oxygen levels in tumor xenografts. The system provides a means of measuring the oxygen content in harvested tumor tissue from specific locations. Oxygen in human tumor xenografts in a murine model was observed for over 1 min. Tissues were mapped in relation to oxygen tension (pO2) readings and sampled for conventional cytological examination. Careful modeling of the pO2 readings over 60 seconds yielded a diffusion coefficient for oxygen at the sensor tip, providing additional diagnostic information about the tissue before sampling. Oxygen level measurement may provide a useful adjunct to the use of biomarkers in tumor diagnosis.Source
McDonald RC, Fischer AH, Rusckowski M. Oxygen Sensor-Guided Fine Needle Biopsy Studies of Human Cancer Xenografts in Mice. bioRxiv [Preprint]. 2024 Jun 1:2024.05.27.596060. doi: 10.1101/2024.05.27.596060. PMID: 38854036; PMCID: PMC11160627.DOI
10.1101/2024.05.27.596060Permanent Link to this Item
http://hdl.handle.net/20.500.14038/53654PubMed ID
38854036Notes
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.Rights
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