We are upgrading the repository! A content freeze is in effect until December 6, 2024. New submissions or changes to existing items will not be allowed during this period. All content already published will remain publicly available for searching and downloading. Updates will be posted in the Website Upgrade 2024 FAQ in the sidebar Help menu. Reach out to escholarship@umassmed.edu with any questions.
Imaging chronic active lesions in multiple sclerosis: a consensus statement
Authors
Bagnato, FrancescaSati, Pascal
Hemond, Christopher C
Elliott, Colm
Gauthier, Susan A
Harrison, Daniel M
Mainero, Caterina
Oh, Jiwon
Pitt, David
Shinohara, Russell T
Smith, Seth A
Trapp, Bruce
Azevedo, Christina J
Calabresi, Peter A
Henry, Roland G
Laule, Cornelia
Ontaneda, Daniel
Rooney, William D
Sicotte, Nancy L
Reich, Daniel S
Absinta, Martina
UMass Chan Affiliations
NeurologyDocument Type
Journal ArticlePublication Date
2024-01-16Keywords
MRI-defined slowly evolving lesionschronic active lesions
iron
microglia
multiple sclerosis
paramagnetic rim lesions
UMCCTS funding
Metadata
Show full item recordAbstract
Chronic active lesions (CAL) are an important manifestation of chronic inflammation in multiple sclerosis and have implications for non-relapsing biological progression. In recent years, the discovery of innovative MRI and PET-derived biomarkers has made it possible to detect CAL, and to some extent quantify them, in the brain of persons with multiple sclerosis, in vivo. Paramagnetic rim lesions on susceptibility-sensitive MRI sequences, MRI-defined slowly expanding lesions on T1-weighted and T2-weighted scans, and 18-kDa translocator protein-positive lesions on PET are promising candidate biomarkers of CAL. While partially overlapping, these biomarkers do not have equivalent sensitivity and specificity to histopathological CAL. Standardization in the use of available imaging measures for CAL identification, quantification and monitoring is lacking. To fast-forward clinical translation of CAL, the North American Imaging in Multiple Sclerosis Cooperative developed a consensus statement, which provides guidance for the radiological definition and measurement of CAL. The proposed manuscript presents this consensus statement, summarizes the multistep process leading to it, and identifies the remaining major gaps in knowledge.Source
Bagnato F, Sati P, Hemond CC, Elliott C, Gauthier SA, Harrison DM, Mainero C, Oh J, Pitt D, Shinohara RT, Smith SA, Trapp B, Azevedo CJ, Calabresi PA, Henry RG, Laule C, Ontaneda D, Rooney WD, Sicotte NL, Reich DS, Absinta M. Imaging chronic active lesions in multiple sclerosis: a consensus statement. Brain. 2024 Sep 3;147(9):2913-2933. doi: 10.1093/brain/awae013. PMID: 38226694; PMCID: PMC11370808.DOI
10.1093/brain/awae013Permanent Link to this Item
http://hdl.handle.net/20.500.14038/53896PubMed ID
38226694Rights
© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. Elements of this work were written by employees of the US Government.ae974a485f413a2113503eed53cd6c53
10.1093/brain/awae013