Lin, Meei-YunSelin, Liisa K.Welsh, Raymond M.2022-08-232022-08-232000-09-012008-11-05Microbes Infect. 2000 Jul;2(9):1025-39.1286-4579 (Print)10967283https://hdl.handle.net/20.500.14038/34100CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system.en-USAnimals; Antigens, Viral; CD8-Positive T-Lymphocytes; Epstein-Barr Virus Infections; Flow Cytometry; Herpesvirus 4, Human; Interferon Type II; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Antigen, T-Cell, alpha-beta; Spleen; T-Lymphocyte Subsets; Virus LatencyLife SciencesMedicine and Health SciencesJournal Articlehttps://escholarship.umassmed.edu/gsbs_sp/764661873gsbs_sp/764