Maeda, KenWest, KimHayasaka, DaisukeEnnis, Francis A.Terajima, Masanori2022-08-232022-08-232005-12-162017-08-22Viral Immunol. 2005;18(4):657-67. <a href="https://doi.org/10.1089/vim.2005.18.657">Link to article on publisher's site</a>0882-8245 (Linking)10.1089/vim.2005.18.65716359232https://hdl.handle.net/20.500.14038/35049The efficiency of prime-boost vaccinations on the induction of T-cell responses to Sin Nombre virus nucleocapsid protein expressed by recombinant vaccinia virus, replication-deficient adenovirus, and plasmid DNA in mice was quantitated by the number of epitope-specific interferon-gamma-producing T cells and cytotoxic T-lymphocyte activity induced. In prime-boost immunizations, all combinations that included the recombinant adenovirus induced a much higher number of epitope-specific interferon-gamma-producing T cells than did other combinations. A single immunization of the recombinant adenovirus was able to induce similarly high levels of epitope-specific interferon-gamma-producing cells, despite the fact that the recombinant adenovirus produces less amount of the Sin Nombre virus nucleocapsid protein.en-USImmunityImmunology and Infectious DiseaseImmunology of Infectious DiseaseInfectious DiseaseJournal Articlehttps://escholarship.umassmed.edu/infdis_pp/26310636638infdis_pp/263