Low, Hoi PangGreco, BeatriceTanahashi, YusukeGallant, JudithJones, Stephen N.Billings-Gagliardi, SusanRecht, Lawrence D.Schwartz, William J.2022-08-232022-08-232009-01-012008-12-18J Neurol Sci. 2009 Jan 15;276(1-2):133-7. Epub 2008 Nov 8. <a href="http://dx.doi.org/10.1016/j.jns.2008.09.037">Link to article on publisher's site</a>0022-510X (Print)10.1016/j.jns.2008.09.03718996543https://hdl.handle.net/20.500.14038/37649Transplantation of neural precursor cells has been proposed as a possible approach for replacing missing or damaged central nervous system myelin. Neonatal and adult myelin-deficient shiverer (shi) mice, bearing a mutation of the myelin basic protein (MBP) gene, have been used extensively as hosts for testing cell engraftment, migration, and myelination, but relatively little progress has been made in reversing shi motor deficits. Here we describe a prenatal cell replacement strategy, showing that embryonic stem cells injected into shi blastocyst embryos can generate chimeric mice with strong and widespread immunoreactive MBP expression throughout the brain and a behavioral (motor) phenotype that appears essentially rescued.en-USStem cellsMyelin basic protein*X-gal histochemistryBlastocyst injectionChimeraOligodendrocytesShiverer miceWhite matterCell BiologyNeurologyNeuroscience and NeurobiologyJournal Articlehttps://escholarship.umassmed.edu/neuro_pp/193683893neuro_pp/193