Freeman, Marc R.2022-08-232022-08-232005-02-112012-05-24Cell. 2005 Feb 11;120(3):292-3. <a href="http://dx.doi.org/10.1016/j.cell.2005.01.021">Link to article on publisher's site</a>0092-8674 (Linking)10.1016/j.cell.2005.01.02115707887https://hdl.handle.net/20.500.14038/38039Though all communication between neurons occurs through synapses, we know surprisingly little about the mechanisms inducing their formation. In this issue of Cell, Barres and colleagues (Christopherson et al., 2005) demonstrate that glial-derived thrombospondins and additional soluble glial-secreted factors regulate synapse assembly and functional maturation.en-USAnimalsCell CommunicationCell DifferentiationCentral Nervous SystemGrowth ConesHumansNeurogliaNeuronal PlasticitySynapsesThrombospondinsNeuroscience and NeurobiologyJournal Articlehttps://escholarship.umassmed.edu/neurobiology_pp/722911187neurobiology_pp/72