Kim, HeesunDing, Yue-HeZhang, GangmingYan, Yong-HongConte, Darryl Jr.Dong, Meng-QiuMello, Craig C.2022-08-232022-08-232021-05-182021-09-02<p>Kim H, Ding YH, Zhang G, Yan YH, Conte D Jr, Dong MQ, Mello CC. HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in <em>C. elegans</em>. Elife. 2021 May 18;10:e63299. doi: 10.7554/eLife.63299. PMID: 34003109; PMCID: PMC8131101. <a href="https://doi.org/10.7554/eLife.63299">Link to article on publisher's site</a></p>2050-084X (Linking)10.7554/eLife.6329934003109https://hdl.handle.net/20.500.14038/41918Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing. The small ubiquitin-like modifier (SUMO) has been shown to promote the formation and maintenance of silent chromatin (called heterochromatin) in yeast, plants, and animals. Here, we show that Argonaute-directed transcriptional silencing in Caenorhabditis elegans requires SUMOylation of the type 1 histone deacetylase HDA-1. Our findings suggest how SUMOylation promotes the association of HDAC1 with chromatin remodeling factors and with a nuclear Argonaute to initiate de novo heterochromatin silencing.en-USCopyright © 2021, Kim et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.http://creativecommons.org/licenses/by/4.0/C. elegansHDAC SUMOylationdevelopmental biologygermlinenuclear argonautAmino Acids, Peptides, and ProteinsDevelopmental BiologyJournal Articlehttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5757&amp;context=oapubs&amp;unstamped=1https://escholarship.umassmed.edu/oapubs/472424636124oapubs/4724