Tsuda, TakehideLopez-Alberola, Robert F.Rogaeva, Evgeny A.Freedman, MorrisRogaev, Evgeny IDrachman, David A.Pollen, Daniel A.Haines, Jonathan L.Liang, Y.McLachlan, Donald R.2022-08-232022-08-231994-07-012009-06-11<p>Tsuda T, Lopez R, Rogaeva EA, Freedman M, Rogaev E, Drachman D, Pollen D, Haines J, Liang Y, McLachlan DR, et al. Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium? Ann Neurol. 1994 Jul;36(1):97-100. doi: 10.1002/ana.410360118. PMID: 8024269. <a href="http://dx.doi.org/10.1002/ana.410360118">Link to article on publisher's site</a></p>0364-5134 (Print)10.1002/ana.4103601188024269https://hdl.handle.net/20.500.14038/37673Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with epsilon 4 is probably not due to linkage disequilibrium.en-USAgedAllelesAlzheimer DiseaseApolipoprotein C-IIApolipoproteins CApolipoproteins EFemaleGene FrequencyHumansJews*Linkage DisequilibriumMale*Polymorphism, GeneticNeurologyNeuroscience and NeurobiologyJournal Articlehttps://escholarship.umassmed.edu/neuro_pp/295869025neuro_pp/295